The cyclopropyl group is of great importance in medicinal chemistry, as it can be leveraged to influence a range of pharmaceutical properties in drug molecules. This report describes a Vitamin B12‐photocatalyzed approach for the cyclopropanation of electron‐deficient alkenes using dichloromethane (CH2Cl2) as the methylene source. The reaction proceeds in good to excellent yields under mild conditions, has excellent functional group compatibility, and is highly chemoselective. The scope could also be extended to the preparation of D2‐cyclopropyl and methyl‐substituted cyclopropyl adducts starting from CD2Cl2and 1,1‐dichloroethane, respectively.
Analysis of vitamin B 12 in seawater and marine sediment porewater using ELISA: Vitamin B 12 analysis in seawater using ELISA
- Award ID(s):
- 0752105
- NSF-PAR ID:
- 10023364
- Date Published:
- Journal Name:
- Limnology and Oceanography: Methods
- Volume:
- 9
- Issue:
- 10
- ISSN:
- 1541-5856
- Page Range / eLocation ID:
- 515 to 523
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
More Like this
-
Abstract -
Abstract The cyclopropyl group is of great importance in medicinal chemistry, as it can be leveraged to influence a range of pharmaceutical properties in drug molecules. This report describes a Vitamin B12‐photocatalyzed approach for the cyclopropanation of electron‐deficient alkenes using dichloromethane (CH2Cl2) as the methylene source. The reaction proceeds in good to excellent yields under mild conditions, has excellent functional group compatibility, and is highly chemoselective. The scope could also be extended to the preparation of D2‐cyclopropyl and methyl‐substituted cyclopropyl adducts starting from CD2Cl2and 1,1‐dichloroethane, respectively.