More Like this

1. Structure–Property–Toxicity Relationships of Graphene Oxide: Role of Surface Chemistry on the Mechanisms of Interaction with Bacteria

   https://doi.org/10.1021/acs.est.9b05057  

   Barrios, Ana C. ; Wang, Yan ; Gilbertson, Leanne M. ; Perreault, François ( November 2019 , Environmental Science & Technology)
2. Diel Profile of Hydroperoxymethyl Thioformate: Evidence for Surface Deposition and Multiphase Chemistry

   https://doi.org/10.1021/acs.est.0c04323  

   Vermeuel, Michael P. ; Novak, Gordon A. ; Jernigan, Christopher M. ; Bertram, Timothy H. ( October 2020 , Environmental Science & Technology)

   null (Ed.)
3. Blood or Serum Exposure Induce Global Transcriptional Changes, Altered Antigenic Profile, and Increased Cytotoxicity by Classical Bordetellae

   https://doi.org/10.3389/fmicb.2018.01969  

   Gestal, Monica C. ; Rivera, Israel ; Howard, Laura K. ; Dewan, Kalyan K. ; Soumana, Illiassou Hamidou ; Dedloff, Margaret ; Nicholson, Tracy L. ; Linz, Bodo ; Harvill, Eric T. ( September 2018 , Frontiers in Microbiology)
4. N ‐Acetylgalactosamine‐Targeted Delivery of Dendrimer‐Doxorubicin Conjugates Influences Doxorubicin Cytotoxicity and Metabolic Profile in Hepatic Cancer Cells

   https://doi.org/10.1002/adhm.201601046  

   Kuruvilla, Sibu P. ; Tiruchinapally, Gopinath ; ElAzzouny, Mahmoud ; ElSayed, Mohamed E. H. ( January 2017 , Advanced Healthcare Materials)

   This study describes the development of targeted, doxorubicin (DOX)‐loaded generation 5 (G5) polyamidoamine dendrimers able to achieve cell‐specific DOX delivery and release into the cytoplasm of hepatic cancer cells. G5 is functionalized with poly(ethylene glycol) (PEG) brushes displaying N‐acetylgalactosamine (NAcGal) ligands to target hepatic cancer cells. DOX is attached to G5 through one of two aromatic azo‐linkages, L3 or L4, achieving eitherP1((NAcGal_β‐PEGc)_16.6‐G5‐(L3‐DOX)_11.6) orP2((NAcGal_β‐PEGc)_16.6‐G5‐(L4‐DOX)_13.4) conjugates. After confirming the conjugates' biocompatibility, flow cytometry studies show P1/P2 achieve 100% uptake into hepatic cancer cells at 30–60 × 10⁻⁹mparticle concentration. This internalization correlates with cytotoxicity against HepG2 cells with 50% inhibitory concentration (IC₅₀) values of 24.8, 1414.0, and 237.8 × 10⁻⁹mfor free DOX, P1, and P2, respectively. Differences in cytotoxicity prompted metabolomics analysis to identify the intracellular release behavior of DOX. Results show that P1/P2 release alternative DOX metabolites than free DOX. Stable isotope tracer studies show that the different metabolites induce different effects on metabolic cycles. Namely, free DOX reduces glycolysis and increases fatty acid oxidation, while P1/P2 increase glycolysis, likely as a response to high oxidative stress. Overall, P1/P2 conjugates offer a platform drug delivery technology for improving hepatic cancer therapy.

    

   more » « less
5. The role of surface morphology on nucleation density limitation during the CVD growth of graphene and the factors influencing graphene wrinkle formation

   https://doi.org/10.1557/adv.2020.73  

   Withanage, Sajith ; Nanayakkara, Tharanga ; Wijewardena, U. Kushan ; Kriisa, Annika ; Mani, R. G. ( January 2019 , MRS Advances)

   ABSTRACT CVD graphene growth typically uses commercially available cold-rolled copper foils, which includes a rich topography with scratches, dents, pits, and peaks. The graphene grown on this topography, even after annealing the foil, tends to include and reflect these topographic features. Further, the transfer of such CVD graphene to a flat substrate using a polymer transfer method also introduces wrinkles. Here, we examine an electropolishing technique for reducing native foil defects, characterize the resulting foil surface, grow single-crystal graphene on the polished foil, and examine the quality of the graphene for such defects. 

   more » « less