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Title: Synthesis of Aldehydes by Organocatalytic Formylation Reactions of Boronic Acids with Glyoxylic Acid
Abstract

Reported herein is a conceptually novel organocatalytic strategy for the formylation of boronic acids. New reactivity is engineered into the α‐amino‐acid‐forming Petasis reaction occurring between aryl boronic acids, amines, and glyoxylic acids to prepare aldehydes. The operational simplicity of the process and its ability to generate structurally diverse and valued aryl, heteroaryl, and α,β‐unsaturated aldehydes containing a wide array of functional groups, demonstrates the practical utility of the new synthetic strategy.

 
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NSF-PAR ID:
10027395
Author(s) / Creator(s):
 ;  ;  ;  ;  ;  ;  ;  ;  
Publisher / Repository:
Wiley Blackwell (John Wiley & Sons)
Date Published:
Journal Name:
Angewandte Chemie
Volume:
129
Issue:
28
ISSN:
0044-8249
Page Range / eLocation ID:
p. 8313-8317
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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