Microinfarcts are small, but strikingly common, ischemic brain lesions in the aging human brain. There is mounting evidence that microinfarcts contribute to vascular cognitive impairment and dementia, but the origins of microinfarcts are unclear. Understanding the vascular pathologies that cause microinfarcts may yield strategies to prevent their occurrence and reduce their deleterious effects on brain function. Current thinking suggests that cortical microinfarcts arise from the occlusion of penetrating arterioles, which are responsible for delivering oxygenated blood to small volumes of tissue. Unexpectedly, pre‐clinical studies have shown that the occlusion of penetrating venules, which drain deoxygenated blood from cortex, lead to microinfarcts that appear identical to those resulting from arteriole occlusion. Here we discuss the idea that cerebral venule pathology could be an overlooked source for brain microinfarcts in humans.
This mixed‐methods sequential explanatory design investigates disciplinary learning gains when engaging in modeling and simulation processes following a programming or a configuring approach. It also investigates the affordances and challenges that students encountered when engaged in these two approaches to modeling and simulation. © 2017 Wiley Periodicals, Inc. Comput Appl Eng Educ 25:352–375, 2017; View this article online at
- PAR ID:
- 10034528
- Publisher / Repository:
- Wiley Blackwell (John Wiley & Sons)
- Date Published:
- Journal Name:
- Computer Applications in Engineering Education
- Volume:
- 25
- Issue:
- 3
- ISSN:
- 1061-3773
- Format(s):
- Medium: X Size: p. 352-375
- Size(s):
- p. 352-375
- Sponsoring Org:
- National Science Foundation
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