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Title: Increased PD ‐L1 expression in breast and colon cancer stem cells
Summary

Here we report the expression of programmed cell death ligand 1/2 (PD‐L1/L2) in breast and colon cancer stem cells (CSCs). The stemness of these cells was confirmed by their surface markers. Using flow cytometry analysis we demonstrated thatPD‐L1 expression was higher inCSCs of both cancers compared to non‐stem like cancer cells. Consistent with this, detection of cellularPD‐L1 proteins by western blot assay also showed increasedPD‐L1 protein inCSCs. In contrast, only trace amounts ofPD‐L2 were detected inCSCs of both cancers. Our results suggest that breast and colon cancers may be sensitive toPD1/PD‐L1 immunotherapy and thus warrant further investigations ofCSCtargetedPD1/PD‐L1 therapy.

 
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PAR ID:
10039039
Author(s) / Creator(s):
 ;  ;  ;  ;  ;  
Publisher / Repository:
Wiley-Blackwell
Date Published:
Journal Name:
Clinical and Experimental Pharmacology and Physiology
Volume:
44
Issue:
5
ISSN:
0305-1870
Page Range / eLocation ID:
p. 602-604
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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