Phase diagrams and free-energy landscapes for model spin-crossover materials with antiferromagnetic-like nearest-neighbor and ferromagnetic-like long-range interactions
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This study investigates the shear rate dependent margination of micro-particles (MPs) with different shapes in blood flow through numerical simulations. We develop a multiscale computational model to handle the fluid–structure interactions involved in the blood flow simulations. The lattice Boltzmann method (LBM) is used to solve the plasma dynamics and a coarse-grained model is employed to capture the dynamics of red blood cells (RBCs) and MPs. These two solvers are coupled together by the immersed boundary method (IBM). The shear rate dependent margination of sphere MPs is firstly investigated. We find that margination of sphere MPs dramatically increases with the increment of wall shear rate ω under 800 s −1 , induced by the breaking of rouleaux in blood flow. However, the margination probability only slowly grows when ω > 800 s −1 . Furthermore, the shape effect of MPs is examined by comparing the margination behaviors of sphere-like, oblate-like and prolate-like MPs under different wall shear rates. We find that the margination of MPs is governed by the interplay of two factors: hydrodynamic collisions with RBCs including the collision frequency and collision displacement of MPs, and near wall dynamics. MPs that demonstrate poor performance in one process such as collision frequency may stand out in the other process like near wall dynamics. Specifically, the ellipsoidal MPs (oblate and prolate) with small aspect ratio (AR) outperform those with large AR regardless of the wall shear rate, due to their better performance in both the collision with RBCs and near wall dynamics. Additionally, we find there exists a transition shear rate region 700 s −1 < ω < 900 s −1 for all of these MPs: the margination probability dramatically increases with the shear rate below this region and slowly grows above this region, similar to sphere MPs. We further use the surface area to volume ratio (SVR) to distinguish different shaped MPs and illustrate their shear rate dependent margination in a contour in the shear rate–SVR plane. It is of significance that we can approximately predict the margination of MPs with a specific SVR. All these simulation results can be potentially applied to guide the design of micro-drug carriers for biomedical applications.more » « less
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Murray, James (Ed.)Abstract TPX2 proteins were first identified in vertebrates as a key mitotic spindle assembly factor. Subsequent studies demonstrated that TPX2 is an intricate protein, with functionally and structurally distinct domains and motifs including Aurora kinase-binding, importin-binding, central microtubule-binding, and C-terminal TPX2 conserved domain, among others. The first plant TPX2-like protein, WAVE-DAMPENED2, was identified in Arabidopsis as a dominant mutation responsible for reducing the waviness of roots grown on slanted agar plates. Each plant genome encodes at least one ‘canonical’ protein with all TPX2 domains and a family of proteins (20 in Arabidopsis) that diversified to contain only some of the domains. Although all plant TPX2-family proteins to date bind microtubules, they function in distinct processes such as cell division, regulation of hypocotyl cell elongation by hormones and light signals, vascular development, or abiotic stress tolerance. Consequently, their expression patterns, regulation, and functions have diverged considerably. Here we summarize the current body of knowledge surrounding plant TPX2-family proteins.more » « less
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Abstract Saturn’s largest moon, Titan, has an Earth-like volatile cycle, but with methane playing the role of water and surface liquid reservoirs geographically isolated at high latitudes. We recreate Titan’s characteristic dry hydroclimate at the equator of an Earth-like climate model without seasons and with water as the condensable by varying a small set of planetary parameters. We use three observationally motivated criteria for Titan-like conditions at the equator: 1) the peak in surface specific humidity is not at the equator, despite it having the warmest annual-mean temperatures; 2) the vertical profile of specific humidity in the equatorial column is nearly constant through the lower troposphere; and 3) the relative humidity near the surface at the equator is significantly lower than saturation (lower than 60%). We find that simply reducing the available water at the equator does not fully reproduce Titan-like conditions. We additionally vary the rotation period and volatility of water to mimic Titan’s slower rotation and more abundant methane vapor. Longer rotation periods coupled with a dry equatorial surface meet fewer of the Titan-like criteria than equivalent experiments with shorter rotation periods. Experiments with higher volatility of water meet more criteria than those with lower volatility, with some of those with the highest volatility meeting all three, demonstrating that an Earth-like planet can display Titan-like climatology by changing only a few physical parameters.more » « less
