A Lewis acid‐catalyzed formal [3+3] cascade annulation strategy for the formation of diverse tricyclic compounds possessing functionalized pyrano[3,2‐c]chromen‐5(2
Brønsted Acid‐Mediated Formal [3+3] Annulation Between Propargylic Alcohols and 1,3‐Diketones
A Brønsted acid‐mediated formal [3+3] cascade annulation of propargylic alcohols with 1,3‐diketones proceeds through a sequential Meyer−Schuster rearrangement/1,2‐addition. This protocol, which has a wide scope and is conducted under an ambient atmosphere, enables access to a broad array of valuable chromenone derivatives related to many natural products in satisfactory yields under mild conditions. This method could be scaled up to the gram scale, which highlights the latent applicability of this transformation.
- NSF-PAR ID:
- 10048323
- Publisher / Repository:
- Wiley Blackwell (John Wiley & Sons)
- Date Published:
- Journal Name:
- Advanced Synthesis & Catalysis
- Volume:
- 360
- Issue:
- 5
- ISSN:
- 1615-4150
- Page Range / eLocation ID:
- p. 870-874
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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