More Like this

1. Medicago truncatula Molybdate Transporter type 1 (MtMOT1.3) is a plasma membrane molybdenum transporter required for nitrogenase activity in root nodules under molybdenum deficiency

   https://doi.org/10.1111/nph.14739  

   Tejada-Jiménez, Manuel ; Gil-Díez, Patricia ; León-Mediavilla, Javier ; Wen, Jiangqi ; Mysore, Kirankumar S. ; Imperial, Juan ; González-Guerrero, Manuel ( December 2017 , New Phytologist)
2. Nodule‐specific Cu + ‐chaperone NCC1 is required for symbiotic nitrogen fixation in Medicago truncatula root nodules

   https://doi.org/10.1111/nph.19360  

   Navarro‐Gómez, Cristina ; León‐Mediavilla, Javier ; Küpper, Hendrik ; Rodríguez‐Simón, Mario ; Paganelli‐López, Alba ; Wen, Jiangqi ; Burén, Stefan ; Mysore, Kirankumar S. ; Bokhari, Syed Nadeem Hussain ; Imperial, Juan ; et al ( November 2023 , New Phytologist)

   Cu⁺‐chaperones are a diverse group of proteins that allocate Cu⁺ions to specific copper proteins, creating different copper pools targeted to specific physiological processes.

   Symbiotic nitrogen fixation carried out in legume root nodules indirectly requires relatively large amounts of copper, for example for energy delivery via respiration, for which targeted copper deliver systems would be required.

   MtNCC1 is a nodule‐specific Cu⁺‐chaperone encoded in theMedicago truncatulagenome, with a N‐terminus Atx1‐like domain that can bind Cu⁺with picomolar affinities. MtNCC1 is able to interact with nodule‐specific Cu⁺‐importer MtCOPT1.MtNCC1is expressed primarily from the late infection zone to the early fixation zone and is located in the cytosol, associated with plasma and symbiosome membranes, and within nuclei. Consistent with its key role in nitrogen fixation,ncc1mutants have a severe reduction in nitrogenase activity and a 50% reduction in copper‐dependent cytochromecoxidase activity.

   A subset of the copper proteome is also affected in thencc1mutant nodules. Many of these proteins can be pulled down when using a Cu⁺‐loaded N‐terminal MtNCC1 moiety as a bait, indicating a role in nodule copper homeostasis and in copper‐dependent physiological processes. Overall, these data suggest a pleiotropic role of MtNCC1 in copper delivery for symbiotic nitrogen fixation.

    

   more » « less
3. Deep Learning–Based Digitally Reconstructed Tomography of the Chest in the Evaluation of Solitary Pulmonary Nodules: A Feasibility Study

   https://doi.org/10.1016/j.acra.2022.05.005  

   Pyrros, Ayis ; Chen, Andrew ; Rodríguez-Fernández, Jorge Mario ; Borstelmann, Stephen M. ; Cole, Patrick A ; Horowitz, Jeanne ; Chung, Jonathan ; Nikolaidis, Paul ; Boddipalli, Viveka ; Siddiqui, Nasir ; et al ( June 2022 , Academic Radiology)
4. Mechanical Modulation of Tumor Nodules under Flow

   https://doi.org/10.1109/TBME.2021.3092641  

   Conrad, Christina ; Moore, Kaitlin ; Polacheck, William ; Rizvi, Imran ; Scarcelli, Giuliano ( June 2021 , IEEE Transactions on Biomedical Engineering)

   null (Ed.)
5. Fast and fully-automated detection and segmentation of pulmonary nodules in thoracic CT scans using deep convolutional neural networks

   https://doi.org/10.1016/j.compmedimag.2019.02.003  

   Huang, Xia ; Sun, Wenqing ; Tseng, Tzu-Liang ; Li, Chunqiang ; Qian, Wei ( June 2019 , Computerized Medical Imaging and Graphics)