skip to main content


Title: Translating Mechanobiology to the Clinic: A Panel Discussion from the 2018 CMBE Conference
The 2018 BMES Cellular and Molecular Bioengineering (CMBE) Conference was organized around the theme of Discovering the Keys: Transformative and Translational Mechanobiology. The conference programming included a panel discussion on Translating Mechanobiology to the Clinic. The goal of the panel was to initiate a dialogue and share pearls of wisdom from participants’ successes and failures in academia and in industry toward translating scientific discoveries in mechanobiology to technology products in the market or toward devices or drugs that impact clinical care. This commentary reviews the major themes and questions discussed during the panel, including defining translational research and how it applies to mechanobiology, the current landscape in translational mechanobiology, the process for translating mechanobiology research, challenges in translating mechanobiology research, and unique opportunities in translating mechanobiology research.  more » « less
Award ID(s):
1748291
NSF-PAR ID:
10076127
Author(s) / Creator(s):
; ; ;
Date Published:
Journal Name:
Cellular and Molecular Bioengineering
ISSN:
1865-5025
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
More Like this
  1. Abstract Accurate determination of the evolutionary relationships between genes is a foundational challenge in biology. Homology—evolutionary relatedness—is in many cases readily determined based on sequence similarity analysis. By contrast, whether or not two genes directly descended from a common ancestor by a speciation event (orthologs) or duplication event (paralogs) is more challenging, yet provides critical information on the history of a gene. Since 2009, this task has been the focus of the Quest for Orthologs (QFO) Consortium. The sixth QFO meeting took place in Okazaki, Japan in conjunction with the 67th National Institute for Basic Biology conference. Here, we report recent advances, applications, and oncoming challenges that were discussed during the conference. Steady progress has been made toward standardization and scalability of new and existing tools. A feature of the conference was the presentation of a panel of accessible tools for phylogenetic profiling and several developments to bring orthology beyond the gene unit—from domains to networks. This meeting brought into light several challenges to come: leveraging orthology computations to get the most of the incoming avalanche of genomic data, integrating orthology from domain to biological network levels, building better gene models, and adapting orthology approaches to the broad evolutionary and genomic diversity recognized in different forms of life and viruses. 
    more » « less
  2. Abstract The 2021 Summer Biomechanics, Bioengineering, and Biotransport Conference (SB3C) featured a workshop titled "The Elephant in the Room: Nuclear Mechanics and Mechanobiology." The goal of this workshop was to provide a perspective from experts in the field on the current understanding of nuclear mechanics and its role in mechanobiology. This paper reviews the major themes and questions discussed during the workshop, including historical context on the initial methods of measuring the mechanical properties of the nucleus and classifying the primary structures dictating nuclear mechanics, physical plasticity of the nucleus, the emerging role of the linker of nucleoskeleton and cytoskeleton (LINC) complex in coupling the nucleus to the cytoplasm and driving the behavior of individual cells and multicellular assemblies, and the computational models currently in use to investigate the mechanisms of gene expression and cell signaling. Ongoing questions and controversies, along with promising future directions, are also discussed. 
    more » « less
  3. This paper examines the effect of translational research on knowledge production and biomedical entrepreneurship across U.S. regions. Researchers have earlier investigated the outputs of translational research by focusing on academic publications. Little attention has been paid to linking translational research to biomedical entrepreneurship. We construct an analytical model based on the knowledge spillover theory of entrepreneurship and the entrepreneurial ecosystem approach to examine the relationship between translational research, biomedical patents, clinical trials, and biomedical entrepreneurship. We test the model across 381 U.S. metropolitan statistical areas using 10 years of panel data related to the NIH Clinical and Translational Science Awards (CTSA) program. CTSA appears to increase the number of biomedical patents and biomedical entrepreneurship as proxied by the NIH Small Business Innovation Research (SBIR) grants. However, the magnitudes of the effects are relatively small. Path analysis shows that the effect of translational research on regional biomedical entrepreneurship is not strongly conveyed through biomedical patents or clinical trials. 
    more » « less
  4. For three days, 300 attendees embodied the subject of groundwater by going underground in the Hyatt San Francisco Airport conference center. This unique conference at the intersections of science and policy, groundwater and agriculture, water quality, and water supply brought together people from over 30 countries and six continents. Groundwater is the lifeline for many rural and agricultural regions around the world. The conference created an opportunity for researchers and practitioners from a variety of agricultural and political systems to share their similar challenges, such as declining water tables, deteriorating water quality, and solutions, such as long-term monitoring and creative engineering. The meeting was a much needed expansion of the 2010 version of this conference. Presentations were expanded to four parallel tracks, and each of the three days was opened with a 2-hour plenary session. A luncheon keynote was given on the first day, and poster sessions were held on two evenings. The conference closed with a high caliber closing panel reflecting on the challenges and opportunities. If you missed the conference—or even if you were there, but missed seeing the other tracks—presentations and videos of more than half the presentations will be publicly available by early September 2016 at the conference website, http://ag-groundwater.org. 
    more » « less
  5. The U.S. National Science Foundation (NSF) celebrated the 20th anniversary of its research funding programs in cybersecurity, and more generally, secure and trustworthy computing, with a panel session at its conference held in June, 2022. The panel members, distinguished researchers in different research areas of trustworthy computing, were asked to comment on what has been learned, what perhaps should be “unlearned,” what still needs to be learned, and the status of education and training in their respective areas of expertise. Laurie Williams covered enterprise security and measuring security, Gene Tsudik commented on cryptographic security, Trent Jaeger addressed computing infrastructure security, Tadayoshi Kohno reviewed security in cyberphysical systems, and Apu Kapadia provided insights on human-centered security. Michael K. Reiter chaired the panel and moderated questions from the audience. This report provides a brief summary of NSF's research programs in the area and an edited transcript of the panel discussion. 
    more » « less