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Title: Lewis Acid‐Catalyzed Annulation of Propargylic Alcohols with ( Z )‐2‐Styryl‐1 H ‐Indoles
Abstract

A novel copper(II) trifluoromethanesulfonate‐catalyzed intermolecular cascade annulation strategy for the construction of a great variety of pentacyclic compounds possessing valuable carbazole fragments was developed employing propargylic alcohols and (Z)‐2‐styryl‐1H‐indoles as the initial substrates. This protocol, which entails a sequential Meyer‐Schuster rearrangement/isomerization/‐cyclization cascade, enables facile and atom‐economical access to various pentacyclic compounds with broad functional‐group tolerance in good yields under mild conditions. The conversion could be efficiently scaled up to gram quantities, accentuating a potential application of this work.

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NSF-PAR ID:
10076933
Author(s) / Creator(s):
 ;  ;  ;  ;  ;  ;  
Publisher / Repository:
Wiley Blackwell (John Wiley & Sons)
Date Published:
Journal Name:
Advanced Synthesis & Catalysis
Volume:
360
Issue:
22
ISSN:
1615-4150
Page Range / eLocation ID:
p. 4441-4445
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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