Interactions between mutations (
A fitness landscape is a map between the genotype and its reproductive success in a given environment. The topography of fitness landscapes largely governs adaptive dynamics, constraining evolutionary trajectories and the predictability of evolution. Theory suggests that this topography can be deformed by mutations that produce substantial changes to the environment. Despite its importance, the deformability of fitness landscapes has not been systematically studied beyond abstract models, and little is known about its reach and consequences in empirical systems. Here we have systematically characterized the deformability of the genome-wide metabolic fitness landscape of the bacterium
- NSF-PAR ID:
- 10077308
- Publisher / Repository:
- Proceedings of the National Academy of Sciences
- Date Published:
- Journal Name:
- Proceedings of the National Academy of Sciences
- Volume:
- 115
- Issue:
- 44
- ISSN:
- 0027-8424
- Page Range / eLocation ID:
- p. 11286-11291
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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