Multiple human behaviors improve early in life, peaking in young adulthood, and declining thereafter. Several properties of brain structure and function progress similarly across the lifespan. Cognitive and neuroscience research has approached aging primarily using associations between a few behaviors, brain functions, and structures. Because of this, the multivariate, global factors relating brain and behavior across the lifespan are not well understood. We investigated the global patterns of associations between 334 behavioral and clinical measures and 376 brain structural connections in 594 individuals across the lifespan. A single-axis associated changes in multiple behavioral domains and brain structural connections (
Recent studies have revealed that brain development is marked by morphological synchronization across brain regions. Regions with shared growth trajectories form structural covariance networks (SCNs) that not only map onto functionally identified cognitive systems, but also correlate with a range of cognitive abilities across the lifespan. Despite advances in within‐network covariance examinations, few studies have examined lifetime patterns of structural relationships across known SCNs. In the current study, we used a big‐data framework and a novel application of covariate‐adjusted restricted cubic spline regression to identify volumetric network trajectories and covariance patterns across 13 networks (
- PAR ID:
- 10078197
- Publisher / Repository:
- Wiley Blackwell (John Wiley & Sons)
- Date Published:
- Journal Name:
- Human Brain Mapping
- Volume:
- 40
- Issue:
- 1
- ISSN:
- 1065-9471
- Page Range / eLocation ID:
- p. 125-136
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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