Proteinaceous liquid-liquid phase separation (LLPS) occurs when a polypeptide coalesces into a dense phase to form a liquid droplet (i.e., condensate) in aqueous solution. In vivo, functional protein-based condensates are often referred to as membraneless organelles (MLOs), which have roles in cellular processes ranging from stress responses to regulation of gene expression. Late embryogenesis abundant (LEA) proteins containing seed maturation protein domains (SMP; PF04927) have been linked to storage tolerance of orthodox seeds. The mechanism by which anhydrobiotic longevity is improved is unknown. Interestingly, the brine shrimp
In preparation for the onset of environmental challenges like overwintering, food limitation, anoxia, or water stress, many invertebrates and certain killifish enter diapause. Diapause is a developmentally‐programed dormancy characterized by suppression of development and metabolism. For embryos of
Studies with anhydrobiotes like
- NSF-PAR ID:
- 10078308
- Publisher / Repository:
- Wiley Blackwell (John Wiley & Sons)
- Date Published:
- Journal Name:
- IUBMB Life
- Volume:
- 70
- Issue:
- 12
- ISSN:
- 1521-6543
- Page Range / eLocation ID:
- p. 1251-1259
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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