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Title: Rhodium(III)‐Catalyzed Synthesis of N ‐(2‐Acetoxyalkyl)isoquinolones from Oxazolines and Alkynes through C−N Bond Formation and Ring‐Opening
Abstract

An atom‐economic approach for the synthesis ofN‐(2‐acetoxyalkyl)isoquinolones from oxazolines and alkynes through rhodium(III)‐catalyzed auto‐tandem reactions involving C−H bond functionalization/C−N bond formation/ring opening/nucleophilic substitution is described. This protocol features high regioselectivity, tolerance of various functional groups, and retention of absolute configuration of chirality. Exploration of the reaction mechanism reveals that Cu(OAc)2not only acts as the oxidant, but also provides acetate to promote the reaction in this process.

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NSF-PAR ID:
10080229
Author(s) / Creator(s):
 ;  ;  ;  ;  
Publisher / Repository:
Wiley Blackwell (John Wiley & Sons)
Date Published:
Journal Name:
Advanced Synthesis & Catalysis
Volume:
361
Issue:
1
ISSN:
1615-4150
Page Range / eLocation ID:
p. 214-218
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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