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A binary mixture of mesoporous silica nanoparticles plus organic polyammonium additive (dye or drug) is cleanly converted upon mild heating into hollow nanoparticles. The remodeled nanoparticle shell is an organized nanoscale assembly of globular additive/silica subunits and cancer cell assays show that a loaded drug additive is bioavailable.
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Synthesis of Inorganic Hollow Nanospheres and their Application in Drug Delivery
Several approaches have been made to synthesize inorganic hollow nanospheres. A dual-template system is the most effective method, usually using surfactants to form mesoporous shells and rigid templates to form interior hollow structures. However, the removal of rigid templates is time consuming and uneconomical. The self-assembly of soft-templates is more convenient and is able to directly construct hollow mesoporous nanoparticles. The soft-templating approach especially the micelles of amphiphilic block copolymers are very helpfulfor creating hollow interiors andporous shell. The hollow void and thickness of shell can be easily tuned by changing either molecular weight of polymer or solution properties. This review focuses on the synthesis of inorganic hollow nanospheres and their application in drug delivery. The large hollow void space with thorough porosity are always beneficial for drug loading and release.
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- Award ID(s):
- 1736173
- PAR ID:
- 10084523
- Publisher / Repository:
- Journal of Nepal Chemical Society
- Date Published:
- Journal Name:
- Soc
- Volume:
- 38
- ISSN:
- 2164-0696
- Page Range / eLocation ID:
- 12-16
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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