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Abstract The first near IR fluorescent probe for the chemoselective and enantioselective recognition of arginine in aqueous solution is reported in this work. This probe, made of a 1,1’‐binaphthyl‐based chiral aldehyde unit and a rhodamine‐based near IR chromophore, in combination with La3+exhibits highly chemoselective as well as enantioselective fluorescent enhancement with arginine at λ=764 nm upon excitation at λ=690 nm. Little or no fluorescent response is observed toward the chirality miss‐matched arginine enantiomer or other common amino acids and their enantiomers. This probe also allows visual discrimination of the arginine enantiomers because of its fast and distinct color change upon interaction with the substrate.
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Fluorescent nanoparticle sensors with tailor-made recognition units and proximate fluorescent reporter groups
The molecular recognition unit of a fluorescent sensor is its most cumbersome part to design and synthesize, but is key to the specificity of the sensor. Molecular imprinting within cross-linked micelles using easily synthesized modular templates allowed us to create analyte-specific binding sites with a nearby fluorescent probe. This strategy makes it straightforward to vary the recognition unit independent of the reporting unit, making the sensor potentially applicable to a wide range of molecular analytes.
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- Award ID(s):
- 1708526
- PAR ID:
- 10088070
- Date Published:
- Journal Name:
- New Journal of Chemistry
- Volume:
- 42
- Issue:
- 12
- ISSN:
- 1144-0546
- Page Range / eLocation ID:
- 9377 to 9380
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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- Free Publicly Accessible Full Text
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Accepted Manuscript1.0
- Journal Article:
- https://doi.org/10.1039/C8NJ01139G
