Mitigating the loss of brain tissue due to age is a major problem for an ageing population. Improving cardiorespiratory fitness has been suggested as a possible strategy, but the influence on brain morphology has not been fully characterized. To investigate the dependent shifts in brain tissue distribution as a function of cardiorespiratory fitness, we used a 3D transport-based morphometry approach. In this study of 172 inactive older adults aged 58–81 (66.5 ± 5.7) years, cardiorespiratory fitness was determined by VO2 peak (ml/kg/min) during graded exercise and brain morphology was assessed through structural magnetic resonance imaging. After correcting for covariates including age (in the fitness model), gender and level of education, we compared dependent tissue shifts with age to those due to VO2 peak. We found a significant association between cardiorespiratory fitness and brain tissue distribution (white matter, r = 0.30, P = 0.003; grey matter, r = 0.40, P < 0.001) facilitated by direct visualization of the brain tissue shifts due to cardiorespiratory fitness through inverse transformation—a key capability of 3D transport-based morphometry. A strong statistical correlation was found between brain tissue changes related to ageing and those associated with lower cardiorespiratory fitness (white matter, r = 0.62, P < 0.001; grey matter, r = 0.74, P < 0.001). In both cases, frontotemporal regions shifted the most while basal ganglia shifted the least. Our results highlight the importance of cardiorespiratory fitness in maintaining brain health later in life. Furthermore, this work demonstrates 3D transport-based morphometry as a novel neuroinformatic technology that may aid assessment of therapeutic approaches for brain ageing and neurodegenerative diseases.
The Brain on Bikes: Voluntary Performance and Hemodynamic Response in the Prefrontal Cortex During Exhaustive Exercise
Cardiovascular and peripheral muscle efficiencies have been largely investigated as valid predictors of physical performance. In sports medicine, maximum oxygen consumption (VO2max) and lactate threshold (LT) are often used to quantify physical fitness in professional and recreational athletes alike. However, only few studies have attempted to establish if a association exists between brain activity and the successful exertion of physical exercise. In particular, it is unclear if factors such as motivation and resilience to fatigue (or lack thereof), which arguably originate within the brain, can be quantitatively related to physical performance. As a first step to improve our understanding of the role of the central nervous system in physical exercise, we investigated the association between cortical oxygenation measured with functional near infrared spectroscopy (fNIRS) and physical performance in healthy young adults during cycling.
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- Award ID(s):
- 1757949
- NSF-PAR ID:
- 10090189
- Date Published:
- Journal Name:
- Conference of the Society of Functional Near Infrared Spectroscopy
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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The relationship between physical activity and mental health, especially depression, is one of the most studied topics in the field of exercise science and kinesiology. Although there is strong consensus that regular physical activity improves mental health and reduces depressive symptoms, some debate the mechanisms involved in this relationship as well as the limitations and definitions used in such studies. Meta-analyses and systematic reviews continue to examine the strength of the association between physical activity and depressive symptoms for the purpose of improving exercise prescription as treatment or combined treatment for depression. This dataset covers 27 review articles (either systematic review, meta-analysis, or both) and 365 primary study articles addressing the relationship between physical activity and depressive symptoms. Primary study articles are manually extracted from the review articles. We used a custom-made workflow (Fu, Yuanxi. (2022). Scopus author info tool (1.0.1) [Python]. https://github.com/infoqualitylab/Scopus_author_info_collection that uses the Scopus API and manual work to extract and disambiguate authorship information for the 392 reports. The author information file (author_list.csv) is the product of this workflow and can be used to compute the co-author network of the 392 articles. This dataset can be used to construct the inclusion network and the co-author network of the 27 review articles and 365 primary study articles. A primary study article is "included" in a review article if it is considered in the review article's evidence synthesis. Each included primary study article is cited in the review article, but not all references cited in a review article are included in the evidence synthesis or primary study articles. The inclusion network is a bipartite network with two types of nodes: one type represents review articles, and the other represents primary study articles. In an inclusion network, if a review article includes a primary study article, there is a directed edge from the review article node to the primary study article node. The attribute file (article_list.csv) includes attributes of the 392 articles, and the edge list file (inclusion_net_edges.csv) contains the edge list of the inclusion network. Collectively, this dataset reflects the evidence production and use patterns within the exercise science and kinesiology scientific community, investigating the relationship between physical activity and depressive symptoms. FILE FORMATS 1. article_list.csv - Unicode CSV 2. author_list.csv - Unicode CSV 3. Chinese_author_name_reference.csv - Unicode CSV 4. inclusion_net_edges.csv - Unicode CSV 5. review_article_details.csv - Unicode CSV 6. supplementary_reference_list.pdf - PDF 7. README.txt - text file UPDATES IN THIS VERSION COMPARED TO V2 (Clarke, Caitlin; Lischwe Mueller, Natalie; Joshi, Manasi Ballal; Fu, Yuanxi; Schneider, Jodi (2022): The Inclusion Network of 27 Review Articles Published between 2013-2018 Investigating the Relationship Between Physical Activity and Depressive Symptoms. University of Illinois at Urbana-Champaign. https://doi.org/10.13012/B2IDB-4614455_V2) - We updated file article_list.csv to fill in a missing value: row 389, article_id 440. We filled in the "date" column as 2016-08, which was missing before.more » « less
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The relationship between physical activity and mental health, especially depression, is one of the most studied topics in the field of exercise science and kinesiology. Although there is strong consensus that regular physical activity improves mental health and reduces depressive symptoms, some debate the mechanisms involved in this relationship as well as the limitations and definitions used in such studies. Meta-analyses and systematic reviews continue to examine the strength of the association between physical activity and depressive symptoms for the purpose of improving exercise prescription as treatment or combined treatment for depression. This dataset covers 27 review articles (either systematic review, meta-analysis, or both) and 365 primary study articles addressing the relationship between physical activity and depressive symptoms. Primary study articles are manually extracted from the review articles. We used a custom-made workflow (Fu, Yuanxi. (2022). Scopus author info tool (1.0.1) [Python]. https://github.com/infoqualitylab/Scopus_author_info_collection that uses the Scopus API and manual work to extract and disambiguate authorship information for the 392 reports. The author information file (author_list.csv) is the product of this workflow and can be used to compute the co-author network of the 392 articles. This dataset can be used to construct the inclusion network and the co-author network of the 27 review articles and 365 primary study articles. A primary study article is "included" in a review article if it is considered in the review article's evidence synthesis. Each included primary study article is cited in the review article, but not all references cited in a review article are included in the evidence synthesis or primary study articles. The inclusion network is a bipartite network with two types of nodes: one type represents review articles, and the other represents primary study articles. In an inclusion network, if a review article includes a primary study article, there is a directed edge from the review article node to the primary study article node. The attribute file (article_list.csv) includes attributes of the 392 articles, and the edge list file (inclusion_net_edges.csv) contains the edge list of the inclusion network. Collectively, this dataset reflects the evidence production and use patterns within the exercise science and kinesiology scientific community, investigating the relationship between physical activity and depressive symptoms. FILE FORMATS 1. article_list.csv - Unicode CSV 2. author_list.csv - Unicode CSV 3. Chinese_author_name_reference.csv - Unicode CSV 4. inclusion_net_edges.csv - Unicode CSV 5. review_article_details.csv - Unicode CSV 6. supplementary_reference_list.pdf - PDF 7. README.txt - text file UPDATES IN THIS VERSION COMPARED TO V1(Clarke, Caitlin; Lischwe Mueller, Natalie; Joshi, Manasi Ballal; Fu, Yuanxi; Schneider, Jodi (2022): The Inclusion Network of 27 Review Articles Published between 2013-2018 Investigating the Relationship Between Physical Activity and Depressive Symptoms. University of Illinois at Urbana-Champaign. https://doi.org/10.13012/B2IDB-4614455_V1) In V1, we did not upload the file "article_list.csv." We uploaded the missing file in this version, and everything else remains the same.more » « less
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The relationship between physical activity and mental health, especially depression, is one of the most studied topics in the field of exercise science and kinesiology. Although there is strong consensus that regular physical activity improves mental health and reduces depressive symptoms, some debate the mechanisms involved in this relationship as well as the limitations and definitions used in such studies. Meta-analyses and systematic reviews continue to examine the strength of the association between physical activity and depressive symptoms for the purpose of improving exercise prescription as treatment or combined treatment for depression. This dataset covers 27 review articles (either systematic review, meta-analysis, or both) and 364 primary study articles addressing the relationship between physical activity and depressive symptoms. Primary study articles are manually extracted from the review articles. We used a custom-made workflow (Fu, Yuanxi. (2022). Scopus author info tool (1.0.1) [Python]. https://github.com/infoqualitylab/Scopus_author_info_collection that uses the Scopus API and manual work to extract and disambiguate authorship information for the 392 reports. The author information file (author_list.csv) is the product of this workflow and can be used to compute the co-author network of the 392 articles. This dataset can be used to construct the inclusion network and the co-author network of the 27 review articles and 365 primary study articles. A primary study article is "included" in a review article if it is considered in the review article's evidence synthesis. Each included primary study article is cited in the review article, but not all references cited in a review article are included in the evidence synthesis or primary study articles. The inclusion network is a bipartite network with two types of nodes: one type represents review articles, and the other represents primary study articles. In an inclusion network, if a review article includes a primary study article, there is a directed edge from the review article node to the primary study article node. The attribute file (article_list.csv) includes attributes of the 391 articles, and the edge list file (inclusion_net_edges.csv) contains the edge list of the inclusion network. Collectively, this dataset reflects the evidence production and use patterns within the exercise science and kinesiology scientific community, investigating the relationship between physical activity and depressive symptoms. FILE FORMATS 1. article_list.csv - Unicode CSV 2. author_list.csv - Unicode CSV 3. Chinese_author_name_reference.csv - Unicode CSV 4. inclusion_net_edges.csv - Unicode CSV 5. review_article_details.csv - Unicode CSV 6. supplementary_reference_list.pdf - PDF 7. README.txt - text filemore » « less
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Accepted Manuscript1.0
- Conference Paper:
- The DOI is not currently available.
