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Title: Iron-catalyzed C(sp 2 )–C(sp 3 ) cross-coupling at low catalyst loading
The iron-catalyzed C(sp 2 )–C(sp 3 ) cross-coupling provides a highly economical route to exceedingly valuable alkylated arenes that are widespread in medicinal chemistry and materials science. Herein, we report an operationally-simple protocol for the selective C(sp 2 )–C(sp 3 ) iron-catalyzed cross-coupling of aryl chlorides with Grignard reagents at low catalyst loading. A broad range of electronically-varied aryl and heteroaryl chlorides underwent the cross-coupling using challenging alkyl organometallics possessing β-hydrogens with high efficiency up to 2000 TON. A notable feature of the protocol is the use of environmentally-friendly cyclic urea ligands. A series of guidelines to predict cross-coupling reactivity of aryl electrophiles is provided.  more » « less
Award ID(s):
1650766
NSF-PAR ID:
10090812
Author(s) / Creator(s):
; ; ;
Date Published:
Journal Name:
Catalysis Science & Technology
Volume:
9
Issue:
5
ISSN:
2044-4753
Page Range / eLocation ID:
1092 to 1097
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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