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   https://doi.org/10.1016/j.tibs.2023.09.011  

   Baumer, Zachary T.; Erber, Luke; Jolley, Elizabeth; Lawrence, Sheldon; Lin, Chuwei; Murakami, Shino; Perez, Veronica; Prall, Wil; Schaening-Burgos, Cassandra; Sylvia, Megan; et al (October 2023, Trends in Biochemical Sciences)
2. Post-Translational Modifications and Diabetes

   https://doi.org/10.3390/biom14030310  

   Sharma, Chiranjeev; Hamza, Abu; Boyle, Emily; Donu, Dickson; Cen, Yana (March 2024, Biomolecules)

   Diabetes and its associated complications have increasingly become major challenges for global healthcare. The current therapeutic strategies involve insulin replacement therapy for type 1 diabetes (T1D) and small-molecule drugs for type 2 diabetes (T2D). Despite these advances, the complex nature of diabetes necessitates innovative clinical interventions for effective treatment and complication prevention. Accumulative evidence suggests that protein post-translational modifications (PTMs), including glycosylation, phosphorylation, acetylation, and SUMOylation, play important roles in diabetes and its pathological consequences. Therefore, the investigation of these PTMs not only sheds important light on the mechanistic regulation of diabetes but also opens new avenues for targeted therapies. Here, we offer a comprehensive overview of the role of several PTMs in diabetes, focusing on the most recent advances in understanding their functions and regulatory mechanisms. Additionally, we summarize the pharmacological interventions targeting PTMs that have advanced into clinical trials for the treatment of diabetes. Current challenges and future perspectives are also provided. 

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3. Towards fully automated post-event data collection and analysis: Pre-event and post-event information fusion

   https://doi.org/10.1016/j.engstruct.2019.109884  

   Lenjani, Ali; Dyke, Shirley J.; Bilionis, Ilias; Yeum, Chul Min; Kamiya, Kenzo; Choi, Jongseong; Liu, Xiaoyu; Chowdhury, Arindam G. (April 2020, Engineering Structures)

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4. Post-translational modifications and chromatin dynamics

   https://doi.org/10.1042/ebc20180067  

   Gilbert, Nick; Allan, James; Tolsma, Thomas O.; Hansen, Jeffrey C. (March 2019, Essays in Biochemistry)

   Abstract The dynamic structure of chromatin is linked to gene regulation and many other biological functions. Consequently, it is of importance to understand the factors that regulate chromatin dynamics. While the in vivo analysis of chromatin has verified that histone post-translational modifications play a role in modulating DNA accessibility, the complex nuclear environment and multiplicity of modifications prevents clear conclusions as to how individual modifications influence chromatin dynamics in the cell. For this reason, in vitro analyses of model reconstituted nucleosomal arrays has been pivotal in understanding the dynamic nature of chromatin compaction and the affects that specific post-translational modifications can have on the higher order chromatin structure. In this mini-review, we briefly describe the dynamic chromatin structures that have been observed in vitro and the environmental conditions that give rise to these various conformational states. Our focus then turns to a discussion of the specific histone post-translational modifications that have been shown to alter formation of these higher order chromatin structures in vitro and how this may relate to the biological state and accessibility of chromatin in vivo. 

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5. White matter microstructural integrity pre- and post-treatment in individuals with chronic post-stroke aphasia

   https://doi.org/10.1016/j.bandl.2022.105163  

   Braun, Emily J.; Billot, Anne; Meier, Erin L.; Pan, Yue; Parrish, Todd B.; Kurani, Ajay S.; Kiran, Swathi (September 2022, Brain and Language)