More Like this

1. Succinate in the tumor microenvironment affects tumor growth and modulates tumor associated macrophages

   https://doi.org/10.1016/j.biomaterials.2023.122292  

   Inamdar, Sahil; Suresh, Abhirami P.; Mangal, Joslyn L.; Ng, Nathan D.; Sundem, Alison; Behbahani, Hoda Shokrollahzadeh; Rubino, Thomas E.; Yaron, Jordan R.; Khodaei, Taravat; Green, Matthew; et al (October 2023, Biomaterials)
2. Tumor Growth with Nutrients: Stability of the Tumor Patches

   https://doi.org/10.1137/22M1542222  

   Kim, Inwon; Lelmi, Jona (October 2023, SIAM Journal on Mathematical Analysis)
3. Organotypic breast tumor model elucidates dynamic remodeling of tumor microenvironment

   https://doi.org/10.1016/j.biomaterials.2020.119853  

   Singh, Sunil; Ray, Lucille A.; Shahi Thakuri, Pradip; Tran, Sydnie; Konopka, Michael C.; Luker, Gary D.; Tavana, Hossein (April 2020, Biomaterials)
4. Mathematical modeling of multicellular tumor spheroids quantifies inter-patient and intra-tumor heterogeneity

   https://doi.org/10.1038/s41540-025-00492-3  

   Malik, Adam A; Nguyen, Kyle C; Nardini, John T; Krona, Cecilia C; Flores, Kevin B; Nelander, Sven (December 2025, npj Systems Biology and Applications)

   Abstract In the study of brain tumors, patient-derived three-dimensional sphere cultures provide an important tool for studying emerging treatments. The growth of such spheroids depends on the combined effects of proliferation and migration of cells, but it is challenging to make accurate distinctions between increase in cell number versus the radial movement of cells. To address this, we formulate a novel model in the form of a system of two partial differential equations (PDEs) incorporating both migration and growth terms, and show that it more accurately fits our data compared to simpler PDE models. We show that traveling-wave speeds are strongly associated with population heterogeneity. Having fitted the model to our dataset we show that a subset of the cell lines are best described by a “Go-or-Grow”-type model, which constitutes a special case of our model. Finally, we investigate whether our fitted model parameters are correlated with patient age and survival. 

   more » « less
5. Immunotherapy discovery on tumor organoid-on-a-chip platforms that recapitulate the tumor microenvironment

   https://doi.org/10.1016/j.addr.2022.114365  

   Zhang, Jie; Tavakoli, Hamed; Ma, Lei; Li, Xiaochun; Han, Lichun; Li, XiuJun (August 2022, Advanced Drug Delivery Reviews)