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1. The production of valuable biopolymer precursors from fructose

   https://doi.org/10.1039/d0gc02315a  

   Liu, Xuan; Leong, Daniel Chee; Sun, Yujie (October 2020, Green Chemistry)

   null (Ed.)

   The increasing demand for green chemical products calls for the exploration of sustainable and renewable carbon resources beyond fossil-based materials, whose utilization inevitably results in environmental concerns. As such, biomass valorisation has attracted increasing attention because biomass is the most widely available and sustainable carbon source. Among the available biomass-derived platform chemicals, 5-hydroxymethylfurfural (HMF) has long been regarded as an attractive candidate for the production of numerous value-added products. Nevertheless, the poor stability, and difficult separation and purification of HMF from fructose dehydration significantly inhibit its large-scale application. Herein, we report a two-step process for the direct production of two biopolymer precursors, 2,5-furandicarboxylic acid (FDCA) and 2,5-bis(hydroxymethyl)furan (BHMF), from fructose, bypassing the isolation of HMF. FDCA and BHMF are much easier to separate and purify from the reaction mixture than HMF, and they both can replace petroleum-based counterparts in the syntheses of many industrially important polymers, ranging from polyesters to polyamides. Optimized fructose dehydration under microwave irradiation achieved a high HMF yield (83%) using a biphasic strategy. The subsequent electrocatalytic conversion of the resulting microwave reaction mixture allowed us to carry out either oxidation or reduction via readily tuning the electrochemical parameters to yield FDCA or BHMF, respectively. The integration of microwave irradiation and electrocatalysis in a flow electrolyzer enabled the direct conversion of readily available fructose to highly valuable FDCA and BHMF without the expensive and challenging step of HMF isolation, suggesting an economically attractive approach for upgrading carbohydrates. 

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2. Comparative Effects of Allulose, Fructose, and Glucose on the Small Intestine

   https://doi.org/10.3390/nu14153230  

   Suzuki, Takuji; Sato, Yuki; Kadoya, Sumire; Takahashi, Takumi; Otomo, Moeko; Kobayashi, Hanna; Aoki, Kai; Kantake, Mai; Sugiyama, Maika; Ferraris, Ronaldo P. (August 2022, Nutrients)

   Despite numerous studies on the health benefits of the rare sugar allulose, its effects on intestinal mucosal morphology and function are unclear. We therefore first determined its acute effects on the small intestinal transcriptome using DNA microarray analysis following intestinal allulose, fructose and glucose perfusion in rats. Expression levels of about 8-fold more genes were altered by allulose compared to fructose and glucose perfusion, suggesting a much greater impact on the intestinal transcriptome. Subsequent pathway analysis indicated that nutrient transport, metabolism, and digestive system development were markedly upregulated, suggesting allulose may acutely stimulate these functions. We then evaluated whether allulose can restore rat small intestinal structure and function when ingested orally following total parenteral nutrition (TPN). We also monitored allulose effects on blood levels of glucagon-like peptides (GLP) 1 and 2 in TPN rats and normal mice. Expression levels of fatty acid binding and gut barrier proteins were reduced by TPN but rescued by allulose ingestion, and paralleled GLP-2 secretion potentially acting as the mechanism mediating the rescue effect. Thus, allulose can potentially enhance disrupted gut mucosal barriers as it can more extensively modulate the intestinal transcriptome relative to glucose and fructose considered risk factors of metabolic disease. 

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3. SÍGAME Simulations of the [{ m{C}},{ m{II}}], [{ m{O}},{ m{I}}], and [{ m{O}},{ m{III}}] Line Emission from Star-forming Galaxies at zsimeq 6

   Olsen, Karen; Greve, Thomas R.; Narayanan, Desika; Thompson, Robert; Davé, Romeel; Niebla Rios, Luis; Stawinski, Stephanie (January 2017, Astrophysical journal)

   Of the almost 40 star-forming galaxies at z≳ 5 (not counting quasi-stellar objects) observed in [{{C}} {{II}}] to date, nearly half are either very faint in [{{C}} {{II}}] or not detected at all, and fall well below expectations based on locally derived relations between star formation rate and [{{C}} {{II}}] luminosity. This has raised questions as to how reliable [{{C}} {{II}}] is as a tracer of star formation activity at these epochs and how factors such as metallicity might affect the [{{C}} {{II}}] emission. Combining cosmological zoom simulations of galaxies with SÍGAME (SImulator of GAlaxy Millimeter/submillimeter Emission), we modeled the multiphased interstellar medium (ISM) and its emission in [{{C}} {{II}}], as well as in [O I] and [O III], from 30 main-sequence galaxies at z≃ 6 with star formation rates ˜3-23 {M}⊙ {yr}}-1, stellar masses ˜ (0.7{--}8)× {10}9 {M}⊙ , and metallicities ˜ (0.1{--}0.4)× {Z}⊙ . The simulations are able to reproduce the aforementioned [{{C}} {{II}}] faintness of some normal star-forming galaxy sources at z≥slant 5. In terms of [O I] and [O III], very few observations are available at z≳ 5, but our simulations match two of the three existing z≳ 5 detections of [O III] and are furthermore roughly consistent with the [O I] and [O III] luminosity relations with star formation rate observed for local starburst galaxies. We find that the [{{C}} {{II}}] emission is dominated by the diffuse ionized gas phase and molecular clouds, which on average contribute ˜66% and ˜27%, respectively. The molecular gas, which constitutes only ˜ 10 % of the total gas mass, is thus a more efficient emitter of [{{C}} {{II}}] than the ionized gas, which makes up ˜85% of the total gas mass. A principal component analysis shows that the [{{C}} {{II}}] luminosity correlates with the star formation activity of a galaxy as well as its average metallicity. The low metallicities of our simulations together with their low molecular gas mass fractions can account for their [{{C}} {{II}}] faintness, and we suggest that these factors may also be responsible for the [{{C}} {{II}}]-faint normal galaxies observed at these early epochs. 

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4. Examining Acid Formation During the Selective Dehydration of Fructose to 5‐Hydroxymethylfurfural in Dimethyl Sulfoxide and Water

   https://doi.org/10.1002/cssc.201803013  

   Whitaker, Mariah R.; Parulkar, Aamena; Ranadive, Pinaki; Joshi, Rutuja; Brunelli, Nicholas A. (April 2019, ChemSusChem)
5. Supercapacitors from high fructose corn syrup-derived activated carbons

   https://doi.org/10.1016/j.mtener.2018.07.002  

   Cao, Wenxin; Yang, Fuqian (September 2018, Materials Today Energy)