skip to main content
US FlagAn official website of the United States government
dot gov icon
Official websites use .gov
A .gov website belongs to an official government organization in the United States.
https lock icon
Secure .gov websites use HTTPS
A lock ( lock ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Explore Research Products in the PAR
It may take a few hours for recently added research products to appear in PAR search results.


Title: Environmental deformations dynamically shift the grid cell spatial metric
In familiar environments, the firing fields of entorhinal grid cells form regular triangular lattices. However, when the geometric shape of the environment is deformed, these time-averaged grid patterns are distorted in a grid scale-dependent and local manner. We hypothesized that this distortion in part reflects dynamic anchoring of the grid code to displaced boundaries, possibly through border cell-grid cell interactions. To test this hypothesis, we first reanalyzed two existing rodent grid rescaling datasets to identify previously unrecognized boundary-tethered shifts in grid phase that contribute to the appearance of rescaling. We then demonstrated in a computational model that boundary-tethered phase shifts, as well as scale-dependent and local distortions of the time-averaged grid pattern, could emerge from border-grid interactions without altering inherent grid scale. Together, these results demonstrate that environmental deformations induce history-dependent shifts in grid phase, and implicate border-grid interactions as a potential mechanism underlying these dynamics.  more » « less
Award ID(s):
1734030
PAR ID:
10099905
Author(s) / Creator(s):
; ;
Date Published:
Journal Name:
eLife
Volume:
7
ISSN:
2050-084X
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
More Like this
  1. ; ; ; ; ; ; ; ; ; (, Nature Neuroscience)
    The cortex has a characteristic layout with specialized functional areas forming distributed large-scale networks. However, substantial work shows striking variation in this organization across people, which relates to differences in behavior. While most previous work treats individual differences as linked to boundary shifts between the borders of regions, here we show that cortical 'variants' also occur at a distance from their typical position, forming ectopic intrusions. Both 'border' and 'ectopic' variants are common across individuals, but differ in their location, network associations, properties of subgroups of individuals, activations during tasks, and prediction of behavioral phenotypes. Border variants also track significantly more with shared genetics than ectopic variants, suggesting a closer link between ectopic variants and environmental influences. This work argues that these two dissociable forms of variation-border shifts and ectopic intrusions-must be separately accounted for in the analysis of individual differences in cortical systems across people. 
    more » « less
  2. ; ; ; (, Hippocampus)
    Abstract Place and grid cells in the hippocampal formation are commonly thought to support a unified and coherent cognitive map of space. This mapping mechanism faces a challenge when a navigator is placed in a familiar environment that has been deformed from its original shape. Under such circumstances, many transformations could plausibly serve to map a navigator's familiar cognitive map to the deformed space. Previous empirical results indicate that the firing fields of rodent place and grid cells stretch or compress in a manner that approximately matches the environmental deformation, and human spatial memory exhibits similar distortions. These effects have been interpreted as evidence that reshaping a familiar environment elicits an analogously reshaped cognitive map. However, recent work has suggested an alternative explanation, whereby deformation‐induced distortions of the grid code are attributable to a mechanism that dynamically anchors grid fields to the most recently experienced boundary, thus causing history‐dependent shifts in grid phase. This interpretation raises the possibility that human spatial memory will exhibit similar history‐dependent dynamics. To test this prediction, we taught participants the locations of objects in a virtual environment and then probed their memory for these locations in deformed versions of this environment. Across three experiments with variable access to visual and vestibular cues, we observed the predicted pattern, whereby the remembered locations of objects were shifted from trial to trial depending on the boundary of origin of the participant's movement trajectory. These results provide evidence for a dynamic anchoring mechanism that governs both neuronal firing and spatial memory. 
    more » « less
  3. ; (, Soft Matter)
    Active fluctuations of tethered membranes with no self-avoidance can be encapsulated by a simple rescaling of the background temperature. The self-avoiding membrane preserves its extended phase even in the presence of very large active fluctuations. 
    more » « less
  4. ; ; (, Journal of the Atmospheric Sciences)
    Abstract The marine atmospheric boundary layer (ABL) and oceanic boundary layer (OBL) are a two-way coupled system. At the ocean surface, the ABL and OBL share surface fluxes of momentum and buoyancy that incorporate variations in sea surface temperature (SST) and currents. To investigate the interactions, a coupled ABL–OBL large-eddy simulation (LES) code is developed and exercised over a range of atmospheric stability. At each time step, the coupling algorithm passes oceanic currents and SST to the atmospheric LES, which in turn computes surface momentum, temperature, and humidity fluxes driving the oceanic LES. Equations for each medium are time advanced using the same time step but utilize different grid resolutions: the horizontal grid resolution in the ocean is approximately four times finer, e.g., (Δxo, Δxa) = (1.22, 4.88) m. Interpolation and anterpolation (its adjoint) routines connect the atmosphere and ocean surface layers. In the simplest setup of a statistically horizontally homogeneous flow, the largest scale ABL turbulent shear-convective rolls leave an imprint on the OBL currents in the upper layers. This result is shown by comparing simulations that use coupling rules that are applied either instantaneously at everyx–ygrid point or averaged across anx–yplane. The spanwise scale of the ABL turbulence is ∼1000 m, while the depth of the OBL is ∼20 m. In these homogeneous, fully coupled cases, the large-scale spatially intermittent turbulent structures in the ABL modulate SST, currents, and the connecting momentum and buoyancy fluxes, but the mean profiles in each medium are only slightly different. 
    more » « less
  5. ; ; (, Journal of Nonlinear Science)
    We analytically derive and numerically simulate a two-dimensional energy functional modelling the effects of a constant electric field on a thin sample of a bent-core liquid crystal in the ferromagnetic SmA-like phase. We start from a three-dimensional domain and show that under proper rescaling and in the limit of small thickness the electric self-interactions term gives rise to boundary terms. We compare our results to previously proposed models. 
    more » « less
  • Citation Formats
  • MLA
  • APA
  • Chicago
  • BibTeX
  • Save / Share this Record
  • Send to Email