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Title: Quantitative chemoproteomic profiling reveals multiple target interactions of spongiolactone derivatives in leukemia cells
The spongiolactones are marine natural products with an unusual rearranged spongiane skeleton and a fused β-lactone ring. These compounds have potential anticancer properties but their mode of action has yet to be explored. Here we employ activity-based protein profiling to identify the targets of a more potent spongiolactone derivative in live cancer cells, and compare these to the targets of a simpler β-lactone. These hits provide the first insights into the covalent mechanism of action of this natural product class.  more » « less
Award ID(s):
1546973
NSF-PAR ID:
10100468
Author(s) / Creator(s):
; ; ; ; ; ; ; ;
Date Published:
Journal Name:
Chemical Communications
Volume:
53
Issue:
95
ISSN:
1359-7345
Page Range / eLocation ID:
12818 to 12821
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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