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   https://doi.org/10.1093/plcell/koad277  

   Marathe, Sarika ; Grotewold, Erich ; Otegui, Marisa S ( January 2024 , The Plant Cell)

   At the heart of all biological processes lies the control of nuclear gene expression, which is primarily achieved through the action of transcription factors (TFs) that generally contain a nuclear localization signal (NLS) to facilitate their transport into the nucleus. However, some TFs reside in the cytoplasm in a transcriptionally inactive state and only enter the nucleus in response to specific signals, which in plants include biotic or abiotic stresses. These extra-nuclear TFs can be found in the cytosol or associated with various membrane systems, including the endoplasmic reticulum and plasma membrane. They may be integral proteins with transmembrane domains or associate peripherally with the lipid bilayer via acylation or membrane-binding domains. Although over 30 plant TFs, most of them involved in stress responses, have been experimentally shown to reside outside the nucleus, computational predictions suggest that this number is much larger. Understanding how extra-nuclear TFs are trafficked into the nucleus is essential for reconstructing transcriptional regulatory networks that govern major cellular pathways in response to biotic and abiotic signals. Here, we provide a perspective on what is known on plant extranuclear-nuclear TF retention, nuclear trafficking, and the post-translational modifications that ultimately enable them to regulate gene expression upon entering the nucleus.

    

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2. Mate Choice: Should I Mate or Should I Go?

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3. "Should I stay or should I go?” Nurses’ Perspectives About Working During the Covid-19 Pandemic in the United States: A Summative Content Analysis Combined with Topic Modelling

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4. Should I bend or should I grow: the mechanisms of droplet-mediated autophagosome formation

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   Schultz, Sebastian W. ; Agudo-Canalejo, Jaime ; Chino, Haruka ; Migliano, Simona M. ; Saito, Chieko ; Koyama-Honda, Ikuko ; Stenmark, Harald ; Brech, Andreas ; Mizushima, Noboru ; Knorr, Roland L. ; et al ( April 2021 , Autophagy)
5. Should I Stay or Should I Go? Automated Vehicles in the Age of Climate Change

   https://doi.org/10.1145/3334480.3375162  

   Sadeghian Borojeni, Shadan ; Meschtscherjakov, Alexander ; Pfleging, Bastian ; Donmez, Birsen ; Riener, Andreas ; Janssen, Christian P. ; Kun, Andrew L. ; Ju, Wendy ; Remy, Christian ; Wintersberger, Philipp ( April 2020 , CHI’20 Extended Abstracts)

   Will automated driving help or hurt our efforts to remedy climate change? The overall impact of transportation and mobility on the global ecosystem is clear: changes to that system can greatly affect climate outcomes. The design of mobility and automotive systems will influence key fac- tors such as driving style, fuel choice, ride sharing, traffic patterns, and total mileage. However, to date, there are few research efforts that explicitly focus on these overlap- ping themes (automated driving & climate changes) within the HCI and AutomotiveUI communities. Our intention is to grow this community and awareness of the related prob- lems. Specifically, in this workshop, we invite designers, researchers, and practitioners from the sustainable HCI, persuasive design, AutomotiveUI, and mobility communities to collaborate in finding ways to make future mobility more sustainable. Using embodied design improvisation and de- sign fiction methods, we will explore the ways that systems affect behavior which then affect the environment. 

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