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Title: Chemoselective amide reductions by heteroleptic fluoroaryl boron Lewis acids
The heteroleptic borane catalyst (C 6 F 5 ) 2 B(CH 2 CH 2 CH 2 )BPin is found to hydrosilylatively reduce amides under mild conditions. Simple tertiary amides can be reduced using Me 2 EtSiH, whereas tertiary benzamides required a more reactive secondary silane, Et 2 SiH 2 , for efficient reduction. The catalytic system described exhibits exceptional chemoselectivity in the reduction of oligoamides and tolerates functionalities which are prone to reduction under similar conditions.  more » « less
Award ID(s):
1726291
PAR ID:
10104952
Author(s) / Creator(s):
; ; ;
Date Published:
Journal Name:
Chemical Communications
Volume:
54
Issue:
46
ISSN:
1359-7345
Page Range / eLocation ID:
5855 to 5858
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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