Bipolar spectrum and unipolar depressive disorders have been associated with distinct and opposite profiles of reward‐related neural activity. These opposite profiles may reflect a differential preexisting vulnerability for both types of disorders. In support, recent ERP studies find that, following reward feedback, a larger reward positivity (RewP) is associated with greater vulnerability for bipolar spectrum disorders, whereas a smaller RewP is associated with greater vulnerability for depression. However, prior studies have investigated only immediate rewards and have not examined dimensions of both bipolar disorder and unipolar depression within the same sample. The present study is the first to investigate feedback‐related ERP correlates of proneness to hypomania and unipolar depressive tendencies within the same sample and to expand our scope to include future rewards. Participants completed a modified time estimation task where the same monetary reward was available immediately or at one of five different future dates. Results revealed proneness to hypomania and unipolar depressive tendencies were related to an elevated and blunted RewP, respectively, but only following immediate rewards (i.e., today). Following rewards in the distant future (e.g., 8 months), proneness to hypomania and depressive tendencies were associated with elevated and blunted amplitudes for the P3, respectively, a subsequent ERP component reflecting motivational salience during extended feedback processing. Furthermore, these opposing profiles were independent of, and significantly different from, one another. These results suggest that feedback‐related ERPs following immediate and future rewards are candidate biomarkers that can physiologically separate vulnerability for bipolar spectrum from unipolar depressive disorders.
Individuals with suicidal thoughts and behaviors experience abnormalities in reward-related processes, yet little is known about specific components or stages of reward processing that are impaired, especially in children. The primary aim of this study was to conduct an investigation of the Initial Response to Reward subconstruct of the National Institute of Mental Health’s Research Domain Criteria in relation to recent suicidal ideation (SI) in children. Participants were 23 children between the ages of 7 and 11 with a history of recent SI and 46 demographically and clinically matched children with no recent SI. Children completed a simple guessing task during which electroencephalographic signals were continuously recorded to isolate the reward positivity (RewP) event-related potential; specifically, we examined change in RewP (∆RewP), quantified as the difference between neural responses to monetary gains and neural responses to monetary losses. Children with recent SI exhibited significantly smaller (i.e., blunted) ∆RewP, providing initial evidence for blunted initial responses to reward in these children.
more » « less- NSF-PAR ID:
- 10114702
- Publisher / Repository:
- SAGE Publications
- Date Published:
- Journal Name:
- Clinical Psychological Science
- Volume:
- 7
- Issue:
- 5
- ISSN:
- 2167-7026
- Page Range / eLocation ID:
- p. 958-968
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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Abstract European Americans view high-intensity, open-mouthed ‘excited’ smiles more positively than Chinese because they value excitement and other high arousal positive states more. This difference is supported by reward-related neural activity, with European Americans showing greater Nucleus Accumbens (NAcc) activity to excited (vs calm) smiles than Chinese. But do these cultural differences generalize to all rewards, and are they related to real-world social behavior? European American (N = 26) and Chinese (N = 27) participants completed social and monetary incentive delay tasks that distinguished between the anticipation and receipt (outcome) of social and monetary rewards while undergoing Functional Magnetic Resonance Imaging (FMRI). The groups did not differ in NAcc activity when anticipating social or monetary rewards. However, as predicted, European Americans showed greater NAcc activity than Chinese when viewing excited smiles during outcome (the receipt of social reward). No cultural differences emerged when participants received monetary outcomes. Individuals who showed increased NAcc activity to excited smiles during outcome had friends with more intense smiles on social media. These findings suggest that culture plays a specific role in modulating reward-related neural responses to excited smiles during outcome, which are associated with real-world relationships.
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Abstract The Reward‐Positivity (RewP) is a frontocentral event‐related potential elicited following reward and punishment feedback. Reinforcement learning theories propose the RewP reflects a reward prediction error that increases following more favorable (vs. unfavorable) outcomes. An alternative perspective, however, proposes this component indexes a salience‐prediction error that increases following more salient outcomes. Evidence from prior studies that included both reward and punishment conditions is mixed, supporting both accounts. However, these studies often varied how feedback stimuli were repeated across reward and punishment conditions. Differences in the frequency of feedback stimuli may drive inconsistencies by introducing salience effects for infrequent stimuli regardless of whether they are associated with rewards or punishments. To test this hypothesis, the current study examined the effect of outcome valence and stimulus frequency on the RewP and neighboring P2 and P3 components in reward, punishment, and neutral contexts across two separate experiments that varied how often feedback stimuli were repeated between conditions. Experiment 1 revealed infrequent feedback stimuli generated overlapping positivity across all three components. However, controlling for stimulus frequency, experiment 2 revealed favorable outcomes that increased RewP and P3 positivity. Together, these results suggest the RewP reflects some combination of reward‐ and salience‐prediction error encoding. Results also indicate infrequent feedback stimuli elicited strong salience effects across all three components that may inflate, eliminate, or reverse outcome valence effects for the RewP and P3. These results resolve several inconsistencies in the literature and have important implications for electrocortical investigations of reward and punishment feedback processing.
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Background Suicidal thoughts and behavior can begin early in childhood and are a leading cause of death in youth. Although specific mechanisms of risk remain largely unknown, theorists and researchers highlight the importance of the parent–child relationship. The current study focused on one aspect of this relationship: the dynamic exchange of facial affect during interactions. Specifically, we examined the relation between children's history of suicidal ideation (SI) and synchrony of facial expressions during positive and negative mother–child interactions.
Methods Participants were 353 mother–child dyads. Of these, 44 dyads included a child with an SI history. Dyads engaged in positive and negative discussions during which their facial electromyography was recorded from mothers and children to index second‐to‐second changes in positive (zygomaticus) and negative (corrugator) facial affect.
Results Child SI dyads were characterized specifically by reduced synchrony of positive facial affect during the positive discussion compared to dyads without child SI.
Conclusions These findings suggest child SI dyads exhibit reduced synchrony of normative positive expressions during mother–child interactions. If replicated and extended in longitudinal research, these results may help to explain one mechanism of risk among children with SI.
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