Cognitive training may partially reverse cognitive deficits in people with HIV (PWH). Previous functional MRI (fMRI) studies demonstrate that working memory training (WMT) alters brain activity during working memory tasks, but its effects on resting brain network organization remain unknown.
To test whether WMT affects PWH brain functional connectivity in resting‐state fMRI (rsfMRI).
A total of 53 PWH (ages 50.7 ± 1.5 years, two women) and 53
Axial single‐shot gradient‐echo echo‐planar imaging at 3.0 T was performed at baseline (TL1), at 1‐month (TL2), and at 6‐months (TL3), after WMT.
All participants had rsfMRI and clinical assessments (including neuropsychological tests) at TL1 before randomization to Cogmed WMT (adaptive training,
Two‐way analyses of variance (ANOVA) on GT metrics and two‐sample
The ventral default mode network (vDMN) eCent differed between PWH and SN groups at TL1 but not at TL2 (
ICA and GT analyses showed that adaptive WMT normalized graph properties of the vDMN in PWH.