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  • Accepted Manuscript: Complete clot ingestion with cyclical ADAPT increases first-pass recanalization and reduces distal embolization.
Title: Complete clot ingestion with cyclical ADAPT increases first-pass recanalization and reduces distal embolization.
BACKGROUND: Evidence is mounting that first-pass complete recanalization during mechanical thrombectomy is associated with better clinical outcomes in patients presenting with an emergent large vessel occlusion. We hypothesize that aspiration achieving complete clot ingestion results in higher first-pass successful recanalization with quantitative reduction in distal emboli. METHODS: A patient-specific cerebrovascular replica was connected to a flow loop. Occlusion of the middle cerebral artery was achieved with clot analogs. Independent variables were the diameter of the aspiration catheter (0.054-0.088in) and aspiration pattern (static versus cyclical). Outcome measures were the first-pass rates of complete clot ingestion, the extent of recanalization, and the particle-size distribution of distal emboli. RESULTS: All aspiration catheters were successfully navigated to the occlusion. Complete clot ingestion during aspiration thrombectomy resulted in first-pass complete recanalization in every experiment, only achieved in 21% of experiments with partial ingestion (P<0.0001). Aspiration through the large bore 0.088in device resulted in the highest rates of complete clot ingestion (90%). Cyclical aspiration significantly increased the rate of complete clot ingestion (OR21 [1.6, 266]; P=0.04). In all experiments, complete clot ingestion resulted in fewer and smaller distal emboli. CONCLUSIONS: Complete clot ingestion results in fewer distal emboli and the highest rates of first-pass complete recanalization. The rate of more » complete ingestion during aspiration thrombectomy is a function of both the inner diameter of the aspiration catheter and use of cyclical aspiration. Funding Source: This study was funded in part by a research grant (NSF Award: 1819491) from the National Science Foundation (NSF). Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation. Conference Proceeding: This paper was presented in part at the 2018 Annual Meeting of the Society of Vascular & Interventional Neurology (SVIN), November 14-17, 2018 in San Diego, CA « less
Authors:
; ; ; ; ; ; ;
Award ID(s):
1819491
Publication Date:
NSF-PAR ID:
10132857
Journal Name:
Journal of neurointerventional surgery
Volume:
11
Issue:
9
Page Range or eLocation-ID:
931-936
ISSN:
1759-8478
Sponsoring Org:
National Science Foundation
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