Apicomplexan parasites replicate within a protective organelle, called the parasitophorous vacuole (PV). The
Aberrant regulation of metabolic kinases by altered redox homeostasis substantially contributes to aging and various diseases, such as diabetes. We found that the catalytic activity of a conserved family of fructosamine-3-kinases (FN3Ks), which are evolutionarily related to eukaryotic protein kinases, is regulated by redox-sensitive cysteine residues in the kinase domain. The crystal structure of the FN3K homolog from
- NSF-PAR ID:
- 10169261
- Publisher / Repository:
- American Association for the Advancement of Science (AAAS)
- Date Published:
- Journal Name:
- Science Signaling
- Volume:
- 13
- Issue:
- 639
- ISSN:
- 1945-0877
- Page Range / eLocation ID:
- Article No. eaax6313
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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