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  • Base-triggered self-amplifying degradable polyurethanes with the ability to translate local stimulation to continuous long-range degradation
Title: Base-triggered self-amplifying degradable polyurethanes with the ability to translate local stimulation to continuous long-range degradation
A new type of base-triggered self-amplifying degradable polyurethane is reported that degrades under mild conditions, with the release of increasing amounts of amine product leading to self-amplified degradation. The polymer incorporates a base-sensitive Fmoc-derivative into every repeating unit to enable highly sensitive amine amplified degradation. A sigmoidal degradation curve for the linear polymer was observed consistent with a self-amplifying degradation mechanism. An analogous cross-linked polyurethane gel was prepared and also found to undergo amplified breakdown. In this case, a trace amount of localized base initiates the degradation, which in turn propagates through the material in an amplified manner. The results demonstrate the potential utility of these new generation polyurethanes in enhanced disposability and as stimuli responsive materials.  more » « less
Award ID(s):
1709718
PAR ID:
10175965
Author(s) / Creator(s):
; ; ; ; ;
Date Published:
Journal Name:
Chemical Science
Volume:
11
Issue:
12
ISSN:
2041-6520
Page Range / eLocation ID:
3326 to 3331
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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