skip to main content
US FlagAn official website of the United States government
dot gov icon
Official websites use .gov
A .gov website belongs to an official government organization in the United States.
https lock icon
Secure .gov websites use HTTPS
A lock ( lock ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.


Title: Linkages of calcium-induced calcium release in a cardiomyocyte simulated by a system of seven coupled partial differential equations
Award ID(s):
1726023
PAR ID:
10200864
Author(s) / Creator(s):
; ; ;
Date Published:
Journal Name:
Involve, a Journal of Mathematics
Volume:
13
Issue:
3
ISSN:
1944-4176
Page Range / eLocation ID:
399 to 424
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
More Like this
  1. Abstract Inhibitors of the mitochondrial calcium uniporter (MCU) are valuable tools for studying the role of mitochondrial Ca2+in various pathophysiological conditions. In this study, a new fluorogenic MCU inhibitor,RuOCou, is presented. This compound is an analogue of the known MCU inhibitor Ru265 that contains fluorescent axial coumarin carboxylate ligands. Upon aquation ofRuOCouand release of the axial coumarin ligands, a simultaneous increase in its MCU‐inhibitory activity and fluorescence intensity is observed. The fluorescence response of this compound enabled its aquation to be monitored in both HeLa cell lysates and live HeLa cells. This fluorogenic prodrug represents a potential theranostic MCU inhibitor that can be leveraged for the treatment of human diseases related to MCU activity. 
    more » « less