Nano SUS (Ultra Fine Grained Stainless-Steel) for Orthopedic Implants
Musculoskeletal conditions such as low back pain, arthritis and other diseases of the joints affect millions of people around the world and are one the leading causes of disability (1). These diseases often require surgery, including total joint replacement in cases of deterioration of the natural joint (2). Serious concern regarding such procedure is the bacteria adhesion and proliferate on the surfaces of these orthopedic implants. Moreover, bacteria have shown the ability to generate resistance against drugs that once could kill them, hence, being more difficult or even impossible to eliminate them. These pathogens are the principal causative agents of two major types of infection in bone: septic arthritis and osteomyelitis, which involve the inflammatory destruction of joint and bone (3). Therefore, there is an unmet need to generate materials capable of showing reduced bacterial adhesion as well as bactericidal effect in order to avoid further health complications. nanoSUS Bio-Tech was founded based on a collaboration between Komatsuseiki Kosakusho Co., Ltd (KSJ:Japan) and Northeastern University (NEU) in 2019. KSJ has been developing ultra-fine-grained stainless steel since 2002 (4, 5). Using this technology, we are able to control the grain size without any changes in the chemical composition of commercially available FDA more »
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NSF-PAR ID:
10202788
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American Institute of Chemical Engineers Conference
1. Vertebral augmentation, which includes vertebroplasty and kyphoplasty, is a minimally invasive procedure to relieve the back pain caused by vertebral compression fracture (VCF) and osteoporosis-related fractures. Vertebroplasty involves the introduction of a percutaneous needle into the vertebral body followed by an image-guided injection of cement directly into the vertebra. The market size for Vertebroplasty is expected to increase from $910 million in 2019, to$1500 million in 2024 with a CAGR of 8.4%, due to the growing demand by increasing geriatric population, rising incidence of spine illness and technological advancements in this field [1]. NanoSUS Bio-Tech (USA) was found based on a collaboration between Komatsuseiki Kosakusho Co., Ltd (Japan) and Northeastern University (NEU) in 2019 [2]. This company manufactures high strength ultra-fine-grained stainless steel with antimicrobial surface. However, nanoSUS has been developing ultra-fine-grained stainless steel since 2002 [3, 4]. Using this technology, we are able to control grain size without any change in chemical composition of commercially available FDA approved stainless steel. We are able to form this stainless steel into a vertebroplasty needle using our precision machining techniques at Komatsuseiki Kosakusho Co., Ltd. We believe this product will reduce the healthcare expenses for patients suffering from VCF due tomore »