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Title: Stabilization of Active Site Dynamics Leads to Increased Activity with 3′-Azido-3′-deoxythymidine Monophosphate for F105Y Mutant Human Thymidylate Kinase
Award ID(s):
1726525
PAR ID:
10215018
Author(s) / Creator(s):
; ;
Date Published:
Journal Name:
ACS Omega
Volume:
5
Issue:
5
ISSN:
2470-1343
Page Range / eLocation ID:
2355 to 2367
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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    The crystal structure of the product of the neutralization reaction between 3-nitrobenzoic acid and pyridine is reported. The entities that crystallized are a pyridinium cation, a 3-nitrobenzoate anion and a 3-nitrobenzoic acid molecule in a 1:1:1 molar ratio, C 5 H 6 N + ·C 7 H 4 NO 4 − ·C 7 H 5 NO 4 . Distinct sets of hydrogen bonds link the pyridinium and benzoate ions (N—H...O) and the acid and benzoate moieties (O—H...O). The hydrogen bonding along with π–π stacking between the acid and benzoate moieties accounts for the long-range ordering of the crystal. 
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