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Title: Broadband Electrical Sensing of a Live Biological Cell with In Situ Single-Connection Calibration
Single-connection in situ calibration using biocompatible solutions is demonstrated in single-cell sensing from 0.5 to 9 GHz. The sensing is based on quickly trapping and releasing a live cell by dielectrophoresis on a coplanar transmission line with a little protrusion in one of its ground electrodes. The same transmission line is used as the calibration standard when covered by various solutions of known permittivities. The results show that the calibration technique may be precise enough to differentiate cells of different nucleus sizes, despite the measured difference being less than 0.01 dB in the deembedded scattering parameters. With better accuracy and throughput, the calibration technique may allow broadband electrical sensing of live cells in a high-throughput cytometer.  more » « less
Award ID(s):
1809623
PAR ID:
10231274
Author(s) / Creator(s):
; ; ; ; ;
Date Published:
Journal Name:
Sensors
Volume:
20
Issue:
14
ISSN:
1424-8220
Page Range / eLocation ID:
3844
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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