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1. When nothing is certain, anything is possible: open innovation and lean approach at MVM

   https://doi.org/10.1111/radm.12453  

   Di Guardo, Maria Chiara; Marku, Elona; Bonivento, Walter Marcello; Castriotta, Manuel; Ferroni, Fernando; Galbiati, Cristiano; Gorini, Giuseppe; Loi, Michela (January 2021, R&D Management)

   null (Ed.)

   Using a participatory observation approach, this paper aims at exploring how public and private organizations have collaborated in response to the COVID-19 pandemic. We examine the case of MechanicalVentilator Milano (MVM), an international project with over 250 contributors and partners; this project aimed to achieve the challenging goal of designing and realizing a mechanical ventilator for mass production in about 6 weeks. The project received the Emergency Use Authorization granted by the U.S. Food and Drug Administration. The MVM ventilator is a reliable, fail-safe, and easy-to-operate mechanical ventilator that can be produced quickly at a large-scale, based on the readily available parts. The success of the MVM case is unique as it adopts open innovation practices to generate technology innovation, in addition to a lean perspective. Through the MVM project description, this study offers a framework that explains the interplay between open innovation and lean approach, highlighting the different internal and external forces and types of collaborations, and offering fine-grained insights in to the role of universities as platforms of multidisciplinary knowledge. This framework might serve as a basis for future theoretical and empirical research, providing practitioners with new best practices that are essential when facing a severe crisis like COVID-19. 

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2. Taxation and Innovation: What Do We Know?

   https://doi.org/10.3386/w27109  

   Akcigit, Ufuk; Stantcheva, Stefanie (November 2021, Innovation and Public Policy)

   Goolsbee, Austan; Jones, Benjamin (Ed.)

   Tax policies are a wide array of tools, commonly used by governments to influence the economy. In this paper, we review the many margins through which tax policies can affect innovation, the main driver of economic growth in the long-run. These margins include the impact of tax policy on i) the quantity and quality of innovation; ii) the geographic mobility of innovation and inventors across U.S. states and countries; iii) the declining business dynamism in the U.S., firm entry, and productivity; iv) the quality composition of firms, inventors, and teams; and v) the direction of research effort, e.g., toward applied versus basic research, or toward dirty versus clean technologies. We give ideas drawn from research on how the design of policy can allow policy makers to foster the most productive firms without wasting public funds on less productive ones. 

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3. Public perceptions of the US innovation system: moderate support but compelling need for reform

   https://doi.org/10.1093/scipol/scae082  

   Budge, Jason_A; Harthorn, Barbara_Herr; Kandlikar, Milind; Satterfield, Terre; Halcomb, Laura (December 2024, Science and Public Policy)

   Abstract Science and innovation policy in the USA often frame publics as the beneficiaries of new technologies, but little research has yet engaged publics on their views of the innovation system (IS)—the combined efforts of government, industry, and universities to produce and promote new technologies. Based on a national public survey (n = 3,010), we identify three dimensions of public judgments about the IS with public policy implications: (1) US publics hold moderate confidence in the IS to produce benefits for them and to respond to public input; (2) they are slightly more critical of innovation-related environmental harm and the accrual of benefits to large corporations; and (3) they strongly support reforms to ensure safe, responsible, and affordable technological innovation. Multivariate regressions indicate variance of judgments by social location and worldviews, finding equity and justice aspects particularly salient in views on the IS. We discuss implications for innovation policy. 

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4. Online Illegal Cryptomarkets

   https://doi.org/10.1146/annurev-soc-090523-052916  

   Haynie, Dana L; Duxbury, Scott W (May 2024, Annual Review of Sociology)

   Cryptomarkets—online markets for illegal goods—have revolutionized the illegal drug trade, constituting about 10% of all drug trades and attracting users to a greater variety and more addictive substances than available in offline drug markets. This review introduces the burgeoning area of sociology research on illegal cryptomarkets, particularly in the realm of drug trade. We emphasize the expanding role of illicit online trade and its relevance for understanding broader exchange challenges encountered in all illegal trade settings. Examining the effects of online illegal trade on consumption and supply-side policing, we also discuss the harm and potential benefits of moving drug exchange from offline to online markets. We argue for a network perspective's efficacy in this research domain, emphasizing its relevance in assessing trade and discussion networks, technical innovation, and market evolution and vulnerabilities. Concluding, we outline future research areas, including market culture, failure, and the impact of online illegal trade on stratification. 

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5. Acoustofluidics for simultaneous nanoparticle-based drug loading and exosome encapsulation

   https://doi.org/10.1038/s41378-022-00374-2  

   Wang, Zeyu; Rich, Joseph; Hao, Nanjing; Gu, Yuyang; Chen, Chuyi; Yang, Shujie; Zhang, Peiran; Huang, Tony Jun (April 2022, Microsystems & Nanoengineering)

   Abstract Nanocarrier and exosome encapsulation has been found to significantly increase the efficacy of targeted drug delivery while also minimizing unwanted side effects. However, the development of exosome-encapsulated drug nanocarriers is limited by low drug loading efficiencies and/or complex, time-consuming drug loading processes. Herein, we have developed an acoustofluidic device that simultaneously performs both drug loading and exosome encapsulation. By synergistically leveraging the acoustic radiation force, acoustic microstreaming, and shear stresses in a rotating droplet, the concentration, and fusion of exosomes, drugs, and porous silica nanoparticles is achieved. The final product consists of drug-loaded silica nanocarriers that are encased within an exosomal membrane. The drug loading efficiency is significantly improved, with nearly 30% of the free drug (e.g., doxorubicin) molecules loaded into the nanocarriers. Furthermore, this acoustofluidic drug loading system circumvents the need for complex chemical modification, allowing drug loading and encapsulation to be completed within a matter of minutes. These exosome-encapsulated nanocarriers exhibit excellent efficiency in intracellular transport and are capable of significantly inhibiting tumor cell proliferation. By utilizing physical forces to rapidly generate hybrid nanocarriers, this acoustofluidic drug loading platform wields the potential to significantly impact innovation in both drug delivery research and applications. 

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