Probing biased activation of mu-opioid receptor by the biased agonist PZM21 using all atom molecular dynamics simulation

Liao, Siyan; Tan, Kai; Floyd, Cecilia; Bong, Daegun; Pino, Michael James; Wu, Chun

doi:10.1016/j.lfs.2021.119026

Technological innovations have become a key driver of societal advancements. Nowhere is this more evident than in the field of machine learning (ML), which has developed algorithmic models that shape our decisions, behaviors, and outcomes. These tools have widespread use, in part, because they can synthesize massive amounts of data to make seemingly objective recommendations. Yet, in the past few years, the ML community has been drawing attention to the need for caution when interpreting and using these models. This is because these models are created by humans, from data generated by humans, whose psychology allows for various biases that impact how the models are developed, trained, tested, and interpreted. As psychologists, we thus face a fork in the road: Down the first path, we can continue to use these models without examining and addressing these critical flaws and rely on computer scientists to try to mitigate them. Down the second path, we can turn our expertise in bias toward this growing field, collaborating with computer scientists to reduce the models’ deleterious outcomes. This article serves to light the way down the second path by identifying how extant psychological research can help examine and curtail bias in ML models.

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