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Title: Synthesis of Diarylated 4‐Pyridylmethyl Ethers via Palladium‐Catalyzed Cross‐Coupling Reactions
Abstract

The direct arylation of weakly acidicsp3‐hybridized C–H bondsviadeprotonated cross‐coupling processes (DCCP) is a challenge. Herein, a palladium(NIXANTPHOS)‐based catalyst for the monoarylation of 4‐pyridylmethyl 2‐aryl ethers to generate diarylated 4‐pyridyl methyl ethers is introduced. Furthermore, under similar conditions, the diarylation of 4‐pyridyl methyl ethers with aryl bromides has been developed. These methods enable the synthesis of new pyridine derivatives, which are common in medicinally active compounds and have applications in materials science.

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NSF-PAR ID:
10235345
Author(s) / Creator(s):
 ;  ;  ;  ;  
Publisher / Repository:
Wiley Blackwell (John Wiley & Sons)
Date Published:
Journal Name:
Advanced Synthesis & Catalysis
Volume:
359
Issue:
11
ISSN:
1615-4150
Format(s):
Medium: X Size: p. 1927-1932
Size(s):
p. 1927-1932
Sponsoring Org:
National Science Foundation
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