Dysregulation of the corticotropin‐releasing factor (
The role and regulation of
These results reveal that repeated cycles of binge drinking alter
To elucidate the role of decorin, a small leucine‐rich proteoglycan, in the degradation of cartilage matrix during the progression of post‐traumatic osteoarthritis (
Three‐month–old decorin‐null (Dcn−/−) and inducible decorin‐knockout (Dcni
In both Dcn−/−and Dcni
In post‐traumatic
Ultra‐high field magnetic resonance imaging (MRI) has obvious advantages in acquiring high‐resolution images. 7 T MRI has been clinically approved and 21.1 T MRI has also been tested on rodents.
To examine the effects of ultra‐high field on mice behavior and neuron activity.
Prospective, animal model.
Ninety‐eight healthy C57BL/6 mice and 18 depression model mice.
11.1–33.0 T
Open field test, elevated plus maze, three‐chambered social test, Morris water maze, tail suspension test, sucrose preference test, blood routine, biochemistry examinations, enzyme‐linked immunosorbent assay, immunofluorescent assay.
The normality of the data was assessed by Shapiro–Wilk test, followed by Student's
Compared to the sham group, healthy C57/6 mice spent more time in the center area (35.12 ± 4.034, increased by 47.19%) in open field test and improved novel index (0.6201 ± 0.02522, increased by 16.76%) in three‐chambered social test a few weeks after 1 hour 11.1–33.0 T SMF exposure. 7 T SMF exposure for 8 hours alleviated the depression state of depression mice, including less immobile time in tail suspension test (58.32% reduction) and higher sucrose preference (increased by 8.80%). Brain tissue analysis shows that 11.1–33.0 T and 7 T SMFs can increase oxytocin by 164.65% and 36.03%, respectively. Moreover, the c‐Fos level in hippocampus region was increased by 14.79%.
11.1–33.0 T
1
Stage 1
Previously, we found that diet‐induced
Myoendothelial feedback was examined in isolated mouse mesenteric arteries, after 6‐weeks diet‐induced
Myoendothelial feedback was significantly (
Diet‐induced
Inhibitory control training and working memory training are 2 cognitive interventions that have been considered for alcohol use disorder (
Participants with
Response rates were satisfactory over the 2‐week intervention period (65% of training tasks completed), and performance on training tasks was consistent with expected effects. A majority of participants indicated that they were satisfied with the study procedures (94.6%), would participate again (97.4%), and would consider incorporating the training task in their daily life (81.1%). Modest reductions in alcohol consumption were observed (e.g., 0.5 drinking day/wk), primarily in the inhibitory control group, and these effects were selective to alcohol use and did not extend to soda consumption.
These findings demonstrate the feasibility and acceptability of utilizing crowdsourcing methods for interventions development. Such a demonstration helps establish the crowdsourcing setting for future large sample studies testing novel interventions for
An essential complement to molecular‐genetic approaches for analyzing the function of the oculomotor circuitry in mice is an understanding of sensory and motor signal processing in the circuit. Although there has been extensive analysis of the signals carried by neurons in the oculomotor circuits of species, such as monkeys, rabbits and goldfish, relatively little in vivo physiology has been done in the oculomotor circuitry of mice. We analyzed the contribution of vestibular and nonvestibular signals to the responses of individual Purkinje cells in the cerebellar flocculus of mice.
We recorded Purkinje cells in the cerebellar flocculus of C57
As in other species, most individual Purkinje cells in mice carried both vestibular and nonvestibular signals, and the most common response across cells was an increase in firing in response to ipsiversive eye movement or ipsiversive head movement. When both the head and eyes were moving, the Purkinje cell responses were approximated as a linear summation of head and eye velocity inputs. Unlike other species, floccular Purkinje cells in mice were considerably more sensitive to eye velocity than head velocity.
The signal content of Purkinje cells in the cerebellar flocculus of mice was qualitatively similar to that in other species. However, the eye velocity sensitivity was higher than in other species, which may reflect a tuning to the smaller range of eye velocities in mice.
