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Title: Regulation of Error-Prone DNA Double-Strand Break Repair and Its Impact on Genome Evolution
Double-strand breaks are one of the most deleterious DNA lesions. Their repair via error-prone mechanisms can promote mutagenesis, loss of genetic information, and deregulation of the genome. These detrimental outcomes are significant drivers of human diseases, including many cancers. Mutagenic double-strand break repair also facilitates heritable genetic changes that drive organismal adaptation and evolution. In this review, we discuss the mechanisms of various error-prone DNA double-strand break repair processes and the cellular conditions that regulate them, with a focus on alternative end joining. We provide examples that illustrate how mutagenic double-strand break repair drives genome diversity and evolution. Finally, we discuss how error-prone break repair can be crucial to the induction and progression of diseases such as cancer.  more » « less
Award ID(s):
1716039
PAR ID:
10253685
Author(s) / Creator(s):
;
Date Published:
Journal Name:
Cells
Volume:
9
Issue:
7
ISSN:
2073-4409
Page Range / eLocation ID:
1657
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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