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Title: The Antimicrobial Peptide Gad‐1 Clears Pseudomonas aeruginosa Biofilms under Cystic Fibrosis Conditions
Abstract Bacterial infections in cystic fibrosis (CF) patients are an emerging health issue and lead to a premature death. CF is a hereditary disease that creates a thick mucus in the lungs that is prone to bacterial biofilm formation, specificallyPseudomonas aeruginosabiofilms. These biofilms are very difficult to treat because many of them have antibiotic resistance that is worsened by the presence of extracellular DNA (eDNA). eDNA helps to stabilize biofilms and can bind antimicrobial compounds to lessen their effects. The metallo‐antimicrobial peptide Gaduscidin‐1 (Gad‐1) eradicates establishedP. aeruginosabiofilms through a combination of modes of action that includes nuclease activity that can cleave eDNA in biofilms. In addition, Gad‐1 exhibits synergistic activity when used with the antibiotics kanamycin and ciprofloxacin, thus making Gad‐1 a new lead compound for the potential treatment of bacterial biofilms in CF patients.  more » « less
Award ID(s):
1715494
PAR ID:
10255871
Author(s) / Creator(s):
 ;  
Publisher / Repository:
Wiley Blackwell (John Wiley & Sons)
Date Published:
Journal Name:
ChemBioChem
Volume:
22
Issue:
9
ISSN:
1439-4227
Format(s):
Medium: X Size: p. 1646-1655
Size(s):
p. 1646-1655
Sponsoring Org:
National Science Foundation
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