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Title: Approaches to Cyclophane‐Types of Cyclopeptide Alkaloids
Abstract

The cyclopeptide alkaloids are cyclic depsipeptides incorporating cyclophanes with polyamide units 13‐, 14‐ and 15‐membered macrocyclic systems. Although various pharmacological activities have been ascribed to cyclopeptide alkaloids from plants of theRhamnaceafamily, these studies have been hampered by their low availability due to the lack of reasonable amounts distributed in nature. Therefore, novel and efficient synthetic approaches should be an important aim, which inspired us to examine how to diversely construct the unique structures of this type of natural products. In this account, several typical strategies are presented in terms of efficient, stereocontrolled and regioselective synthesis of cyclopeptide alkaloids.

 
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NSF-PAR ID:
10259698
Author(s) / Creator(s):
 ;  
Publisher / Repository:
Wiley Blackwell (John Wiley & Sons)
Date Published:
Journal Name:
The Chemical Record
Volume:
21
Issue:
4
ISSN:
1527-8999
Page Range / eLocation ID:
p. 906-923
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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