Directed C−H functionalization has been realized as a complimentary technique to achieve borylation at a distal position of aliphatic amines. Here, we demonstrated the oxidative borylation at the distal δ‐position of aliphatic amines using various borylating agents, a palladium catalyst, and a rightly tuned ligand in the presence of a cheap oxidant. Moreover, an organopalladium δ‐C(sp3)‐H‐activated intermediate has been isolated and crystallographically characterized to get mechanistic insight.
Ligand‐Enabled δ‐C(sp 3 )−H Borylation of Aliphatic Amines
Directed C−H functionalization has been realized as a complimentary technique to achieve borylation at a distal position of aliphatic amines. Here, we demonstrated the oxidative borylation at the distal δ‐position of aliphatic amines using various borylating agents, a palladium catalyst, and a rightly tuned ligand in the presence of a cheap oxidant. Moreover, an organopalladium δ‐C(sp3)‐H‐activated intermediate has been isolated and crystallographically characterized to get mechanistic insight.
more » « less- Award ID(s):
- 2029932
- PAR ID:
- 10273359
- Publisher / Repository:
- Wiley Blackwell (John Wiley & Sons)
- Date Published:
- Journal Name:
- Angewandte Chemie International Edition
- Volume:
- 60
- Issue:
- 33
- ISSN:
- 1433-7851
- Page Range / eLocation ID:
- p. 18194-18200
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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