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Abstract Transition metal‐catalyzed, non‐enzymatic nitrene transfer (NT) reactions to selectively transform C−H and C=C bonds to new C−N bonds are a powerful strategy to streamline the preparation of valuable amine building blocks. However, many catalysts for these reactions use environmentally unfriendly solvents that include dichloromethane, chloroform, 1,2‐dichloroethane and benzene. We developed a high‐throughput experimentation (HTE) protocol for heterogeneous NT reaction mixtures to enable rapid screening of a broad range of solvents for this chemistry. Coupled with the American Chemical Society Pharmaceutical Roundtable (ACSPR) solvent tool, we identified several attractive replacements for chlorinated solvents. Selected catalysts for NT were compared and contrasted using our HTE protocol, including silver supported byN‐dentate ligands, dinuclear Rh complexes and Fe/Mn phthalocyanine catalysts.
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Dinuclear Silver Complexes in Catalysis
Abstract Over the past two decades, there has been a substantial increase in the number of synthetically useful transformations catalyzed by silver. Across the range of silver‐catalyzed reactions that have been reported, dinuclear species often emerge as a common feature, either as the (pre‐)catalysts themselves or as intermediates during catalysis. This Minireview explores the role of dinuclear silver complexes in homogeneous catalysis, which we hope will aid in the development of improved design principles for silver catalysts.
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- Award ID(s):
- 1956197
- PAR ID:
- 10275031
- Publisher / Repository:
- Wiley Blackwell (John Wiley & Sons)
- Date Published:
- Journal Name:
- Angewandte Chemie International Edition
- Volume:
- 60
- Issue:
- 42
- ISSN:
- 1433-7851
- Page Range / eLocation ID:
- p. 22614-22622
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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