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1. Application of a Convolutional Neural Network to Distinguish Burkitt Lymphoma From Diffuse Large B-Cell Lymphoma

   https://doi.org/10.1093/ajcp/aqy099.286  

   Mohlman, Jeffrey; Leventhal, Samuel; Venkat, Aniketh; Gyulassy, Attila; Pascucci, Valerio; Salama, Mohamed (September 2018, American Journal of Clinical Pathology)
2. Optimized Doxorubicin Chemotherapy for Diffuse Large B-cell Lymphoma Exploits Nanocarrier Delivery to Transferrin Receptors

   https://doi.org/10.1158/0008-5472.CAN-20-2674  

   Arumov, Artavazd; Liyanage, Piumi Y.; Trabolsi, Asaad; Roberts, Evan R.; Li, Lingxiao; Ferreira, Braulio C.L.B.; Gao, Zhen; Ban, Yuguang; Newsam, Austin D.; Taggart, Melissa W.; et al (February 2021, Cancer Research)

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3. Polyomavirus-associated Disseminated T-cell Lymphoma in a Colony of Zebra Finches (Taeniopygia guttata)

   https://doi.org/10.30802/AALAS-CM-23-000011  

   Shuster, Katherine A; Yang, Tzushan S; Snyder, Kate T; Creanza, Nicole; Mitchell, Patrick K; Goodman, Laura B; Grenier, Jennifer K; Tataryn, Nicholas M; Himmel, Lauren E; Gibson-Corley, Katherine N (January 2023, Comparative Medicine)

   Four zebra finches in a closed research colony presented with variable clinical signs, including masses, skin lesions,shivering, and/or ruffled feathers. These birds were not responsive to treatment efforts; 3 died and one was euthanized. All4 were submitted for necropsy to determine the cause of the clinical signs. Gross necropsy and histopathologic findings fromall birds resulted in a diagnosis of round cell neoplasia in multiple organs, including the skin, liver, kidney, and reproductivetract, with intranuclear inclusion bodies in the neoplastic cells. In all 4 cases, immunohistochemical staining showed strongimmunoreactivity for CD3 in 70% to 80% of the neoplastic round cells, with a relatively small subset that were immunopositivefor Pax5. These findings supported a diagnosis of T-cell lymphoma. Frozen liver tissue from one case was submittedfor next-generation sequencing (NGS), which revealed viral RNA with 100% sequence homology to canary polyomavirusstrain 34639 that had originally been identified in a European goldfinch. Formalin-fixed paraffin-embedded scrolls fromanother case were also submitted for NGS, which revealed viral RNA with 97.2% sequence homology to canary polyomavirusstrain 37273 that had originally been identified in a canary. To localize the virus in situ, RNAscope hybridizationwas performed using a probe designed to target the VP1 gene of the sequenced virus in frozen liver tissue. In all 4 cases,disseminated and robust hybridization signals were detected in neoplastic cells. These findings indicate that polyomaviruseshave the potential to be oncogenic in zebra finches. 

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4. Recombinant expression, characterization, and quantification in human cancer cell lines of the Anaplastic Large-Cell Lymphoma-characteristic NPM-ALK fusion protein

   https://doi.org/10.1038/s41598-020-61936-w  

   Kourentzi, Katerina; Crum, Mary; Patil, Ujwal; Prebisch, Ana; Chavan, Dimple; Vu, Binh; Zeng, Zihua; Litvinov, Dmitri; Zu, Youli; Willson, Richard C. (December 2020, Scientific Reports)
5. Glycerol monolaurate inhibition of human B cell activation

   https://doi.org/10.1038/s41598-022-17432-4  

   Fosdick, Micaela G.; Loftus, Shannon; Phillips, Isabella; Zacharias, Zeb R.; Houtman, Jon C. D. (August 2022, Scientific Reports)

   Abstract Glycerol monolaurate (GML) is a naturally occurring antimicrobial agent used commercially in numerous products and food items. GML is also used as a homeopathic agent and is being clinically tested to treat several human diseases. In addition to its anti-microbial function, GML suppresses immune cell proliferation and inhibits primary human T cell activation. GML suppresses T cell activation by altering membrane dynamics and disrupting the formation of protein clusters necessary for intracellular signaling. The ability of GML to disrupt cellular membranes suggests it may alter other cell types. To explore this possibility, we tested how GML affects human B cells. We found that GML inhibits BCR-induced cytokine production, phosphorylation of signaling proteins, and protein clustering, while also changing cellular membrane dynamics and dysregulating cytoskeleton rearrangement. Although similar, there are also differences between how B cells and T cells respond to GML. These differences suggest that unique intrinsic features of a cell may result in differential responses to GML treatment. Overall, this study expands our understanding of how GML impacts the adaptive immune response and contributes to a broader knowledge of immune modulating monoglycerides. 

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