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Title: Examination of Staphylococcus aureus Prophages Circulating in Egypt
Staphylococcus aureus infections are of growing concern given the increased incidence of antibiotic resistant strains. Egypt, like several other countries, has seen alarming increases in methicillin-resistant S. aureus (MRSA) infections. This species can rapidly acquire genes associated with resistance, as well as virulence factors, through mobile genetic elements, including phages. Recently, we sequenced 56 S. aureus genomes from Alexandria Main University Hospital in Alexandria, Egypt, complementing 17 S. aureus genomes publicly available from other sites in Egypt. In the current study, we found that the majority (73.6%) of these strains contain intact prophages, including Biseptimaviruses, Phietaviruses, and Triaviruses. Further investigation of these prophages revealed evidence of horizontal exchange of the integrase for two of the prophages. These Egyptian S. aureus prophages are predicted to encode numerous virulence factors, including genes associated with immune evasion and toxins, including the Panton–Valentine leukocidin (PVL)-associated genes lukF-PV/lukS-PV. Thus, prophages are likely to be a major contributor to the virulence of S. aureus strains in circulation in Egypt.  more » « less
Award ID(s):
1661357
NSF-PAR ID:
10284133
Author(s) / Creator(s):
; ; ; ; ; ;
Date Published:
Journal Name:
Viruses
Volume:
13
Issue:
2
ISSN:
1999-4915
Page Range / eLocation ID:
337
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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