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1. The Temple University Digital Pathology Corpus: The Breast Tissue Subset

   https://doi.org/10.1109/SPMB52430.2021.9672275  

   Wevodau, Z. ; Doshna, B. ; Jhala, N. ; Akhtar, I. ; Obeid, I. ; Picone, J. ( December 2021 , Proceedings of the IEEE Signal Processing in Medicine and Biology Symposium (SPMB))

   Obeid, I. (Ed.)

   The Neural Engineering Data Consortium (NEDC) is developing the Temple University Digital Pathology Corpus (TUDP), an open source database of high-resolution images from scanned pathology samples [1], as part of its National Science Foundation-funded Major Research Instrumentation grant titled “MRI: High Performance Digital Pathology Using Big Data and Machine Learning” [2]. The long-term goal of this project is to release one million images. We have currently scanned over 100,000 images and are in the process of annotating breast tissue data for our first official corpus release, v1.0.0. This release contains 3,505 annotated images of breast tissue including 74 patients with cancerous diagnoses (out of a total of 296 patients). In this poster, we will present an analysis of this corpus and discuss the challenges we have faced in efficiently producing high quality annotations of breast tissue. It is well known that state of the art algorithms in machine learning require vast amounts of data. Fields such as speech recognition [3], image recognition [4] and text processing [5] are able to deliver impressive performance with complex deep learning models because they have developed large corpora to support training of extremely high-dimensional models (e.g., billions of parameters). Other fields that do not have access to such data resources must rely on techniques in which existing models can be adapted to new datasets [6]. A preliminary version of this breast corpus release was tested in a pilot study using a baseline machine learning system, ResNet18 [7], that leverages several open-source Python tools. The pilot corpus was divided into three sets: train, development, and evaluation. Portions of these slides were manually annotated [1] using the nine labels in Table 1 [8] to identify five to ten examples of pathological features on each slide. Not every pathological feature is annotated, meaning excluded areas can include focuses particular to these labels that are not used for training. A summary of the number of patches within each label is given in Table 2. To maintain a balanced training set, 1,000 patches of each label were used to train the machine learning model. Throughout all sets, only annotated patches were involved in model development. The performance of this model in identifying all the patches in the evaluation set can be seen in the confusion matrix of classification accuracy in Table 3. The highest performing labels were background, 97% correct identification, and artifact, 76% correct identification. A correlation exists between labels with more than 6,000 development patches and accurate performance on the evaluation set. Additionally, these results indicated a need to further refine the annotation of invasive ductal carcinoma (“indc”), inflammation (“infl”), nonneoplastic features (“nneo”), normal (“norm”) and suspicious (“susp”). This pilot experiment motivated changes to the corpus that will be discussed in detail in this poster presentation. To increase the accuracy of the machine learning model, we modified how we addressed underperforming labels. One common source of error arose with how non-background labels were converted into patches. Large areas of background within other labels were isolated within a patch resulting in connective tissue misrepresenting a non-background label. In response, the annotation overlay margins were revised to exclude benign connective tissue in non-background labels. Corresponding patient reports and supporting immunohistochemical stains further guided annotation reviews. The microscopic diagnoses given by the primary pathologist in these reports detail the pathological findings within each tissue site, but not within each specific slide. The microscopic diagnoses informed revisions specifically targeting annotated regions classified as cancerous, ensuring that the labels “indc” and “dcis” were used only in situations where a micropathologist diagnosed it as such. Further differentiation of cancerous and precancerous labels, as well as the location of their focus on a slide, could be accomplished with supplemental immunohistochemically (IHC) stained slides. When distinguishing whether a focus is a nonneoplastic feature versus a cancerous growth, pathologists employ antigen targeting stains to the tissue in question to confirm the diagnosis. For example, a nonneoplastic feature of usual ductal hyperplasia will display diffuse staining for cytokeratin 5 (CK5) and no diffuse staining for estrogen receptor (ER), while a cancerous growth of ductal carcinoma in situ will have negative or focally positive staining for CK5 and diffuse staining for ER [9]. Many tissue samples contain cancerous and non-cancerous features with morphological overlaps that cause variability between annotators. The informative fields IHC slides provide could play an integral role in machine model pathology diagnostics. Following the revisions made on all the annotations, a second experiment was run using ResNet18. Compared to the pilot study, an increase of model prediction accuracy was seen for the labels indc, infl, nneo, norm, and null. This increase is correlated with an increase in annotated area and annotation accuracy. Model performance in identifying the suspicious label decreased by 25% due to the decrease of 57% in the total annotated area described by this label. A summary of the model performance is given in Table 4, which shows the new prediction accuracy and the absolute change in error rate compared to Table 3. The breast tissue subset we are developing includes 3,505 annotated breast pathology slides from 296 patients. The average size of a scanned SVS file is 363 MB. The annotations are stored in an XML format. A CSV version of the annotation file is also available which provides a flat, or simple, annotation that is easy for machine learning researchers to access and interface to their systems. Each patient is identified by an anonymized medical reference number. Within each patient’s directory, one or more sessions are identified, also anonymized to the first of the month in which the sample was taken. These sessions are broken into groupings of tissue taken on that date (in this case, breast tissue). A deidentified patient report stored as a flat text file is also available. Within these slides there are a total of 16,971 total annotated regions with an average of 4.84 annotations per slide. Among those annotations, 8,035 are non-cancerous (normal, background, null, and artifact,) 6,222 are carcinogenic signs (inflammation, nonneoplastic and suspicious,) and 2,714 are cancerous labels (ductal carcinoma in situ and invasive ductal carcinoma in situ.) The individual patients are split up into three sets: train, development, and evaluation. Of the 74 cancerous patients, 20 were allotted for both the development and evaluation sets, while the remain 34 were allotted for train. The remaining 222 patients were split up to preserve the overall distribution of labels within the corpus. This was done in hope of creating control sets for comparable studies. Overall, the development and evaluation sets each have 80 patients, while the training set has 136 patients. In a related component of this project, slides from the Fox Chase Cancer Center (FCCC) Biosample Repository (https://www.foxchase.org/research/facilities/genetic-research-facilities/biosample-repository -facility) are being digitized in addition to slides provided by Temple University Hospital. This data includes 18 different types of tissue including approximately 38.5% urinary tissue and 16.5% gynecological tissue. These slides and the metadata provided with them are already anonymized and include diagnoses in a spreadsheet with sample and patient ID. We plan to release over 13,000 unannotated slides from the FCCC Corpus simultaneously with v1.0.0 of TUDP. Details of this release will also be discussed in this poster. Few digitally annotated databases of pathology samples like TUDP exist due to the extensive data collection and processing required. The breast corpus subset should be released by November 2021. By December 2021 we should also release the unannotated FCCC data. We are currently annotating urinary tract data as well. We expect to release about 5,600 processed TUH slides in this subset. We have an additional 53,000 unprocessed TUH slides digitized. Corpora of this size will stimulate the development of a new generation of deep learning technology. In clinical settings where resources are limited, an assistive diagnoses model could support pathologists’ workload and even help prioritize suspected cancerous cases. ACKNOWLEDGMENTS This material is supported by the National Science Foundation under grants nos. CNS-1726188 and 1925494. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation. REFERENCES [1] N. Shawki et al., “The Temple University Digital Pathology Corpus,” in Signal Processing in Medicine and Biology: Emerging Trends in Research and Applications, 1st ed., I. Obeid, I. Selesnick, and J. Picone, Eds. New York City, New York, USA: Springer, 2020, pp. 67 104. https://www.springer.com/gp/book/9783030368432. [2] J. Picone, T. Farkas, I. Obeid, and Y. Persidsky, “MRI: High Performance Digital Pathology Using Big Data and Machine Learning.” Major Research Instrumentation (MRI), Division of Computer and Network Systems, Award No. 1726188, January 1, 2018 – December 31, 2021. https://www. isip.piconepress.com/projects/nsf_dpath/. [3] A. Gulati et al., “Conformer: Convolution-augmented Transformer for Speech Recognition,” in Proceedings of the Annual Conference of the International Speech Communication Association (INTERSPEECH), 2020, pp. 5036-5040. https://doi.org/10.21437/interspeech.2020-3015. [4] C.-J. Wu et al., “Machine Learning at Facebook: Understanding Inference at the Edge,” in Proceedings of the IEEE International Symposium on High Performance Computer Architecture (HPCA), 2019, pp. 331–344. https://ieeexplore.ieee.org/document/8675201. [5] I. Caswell and B. Liang, “Recent Advances in Google Translate,” Google AI Blog: The latest from Google Research, 2020. [Online]. Available: https://ai.googleblog.com/2020/06/recent-advances-in-google-translate.html. [Accessed: 01-Aug-2021]. [6] V. Khalkhali, N. Shawki, V. Shah, M. Golmohammadi, I. Obeid, and J. Picone, “Low Latency Real-Time Seizure Detection Using Transfer Deep Learning,” in Proceedings of the IEEE Signal Processing in Medicine and Biology Symposium (SPMB), 2021, pp. 1 7. https://www.isip. piconepress.com/publications/conference_proceedings/2021/ieee_spmb/eeg_transfer_learning/. [7] J. Picone, T. Farkas, I. Obeid, and Y. Persidsky, “MRI: High Performance Digital Pathology Using Big Data and Machine Learning,” Philadelphia, Pennsylvania, USA, 2020. https://www.isip.piconepress.com/publications/reports/2020/nsf/mri_dpath/. [8] I. Hunt, S. Husain, J. Simons, I. Obeid, and J. Picone, “Recent Advances in the Temple University Digital Pathology Corpus,” in Proceedings of the IEEE Signal Processing in Medicine and Biology Symposium (SPMB), 2019, pp. 1–4. https://ieeexplore.ieee.org/document/9037859. [9] A. P. Martinez, C. Cohen, K. Z. Hanley, and X. (Bill) Li, “Estrogen Receptor and Cytokeratin 5 Are Reliable Markers to Separate Usual Ductal Hyperplasia From Atypical Ductal Hyperplasia and Low-Grade Ductal Carcinoma In Situ,” Arch. Pathol. Lab. Med., vol. 140, no. 7, pp. 686–689, Apr. 2016. https://doi.org/10.5858/arpa.2015-0238-OA. 

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2. Statistical Analysis of Imbalanced Classification with Training Size Variation and Subsampling on Datasets of Research Papers in Biomedical Literature

   Dixon, J ; Rahman, M. ( December 2023 , Machine Learning and Knowledge Extraction)

   The overall purpose of this paper is to demonstrate how data preprocessing, training size variation, and subsampling can dynamically change the performance metrics of imbalanced text classification. The methodology encompasses using two different supervised learning classification approaches of feature engineering and data preprocessing with the use of five machine learning classifiers, five imbalanced sampling techniques, specified intervals of training and subsampling sizes, statistical analysis using R and tidyverse on a dataset of 1000 portable document format files divided into five labels from the World Health Organization Coronavirus Research Downloadable Articles of COVID-19 papers and PubMed Central databases of non-COVID-19 papers for binary classification that affects the performance metrics of precision, recall, receiver operating characteristic area under the curve, and accuracy. One approach that involves labeling rows of sentences based on regular expressions significantly improved the performance of imbalanced sampling techniques verified by performing statistical analysis using a t-test documenting performance metrics of iterations versus another approach that automatically labels the sentences based on how the documents are organized into positive and negative classes. The study demonstrates the effectiveness of ML classifiers and sampling techniques in text classification datasets, with different performance levels and class imbalance issues observed in manual and automatic methods of data processing. 

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3. Text and metadata extraction from scanned Arabic documents using support vector machines

   https://doi.org/10.1177/0165551520961256  

   Qin, Wenda ; Elanwar, Randa ; Betke, Margrit ( April 2022 , Journal of Information Science)

   Text information in scanned documents becomes accessible only when extracted and interpreted by a text recognizer. For a recognizer to work successfully, it must have detailed location information about the regions of the document images that it is asked to analyse. It will need focus on page regions with text skipping non-text regions that include illustrations or photographs. However, text recognizers do not work as logical analyzers. Logical layout analysis automatically determines the function of a document text region, that is, it labels each region as a title, paragraph, or caption, and so on, and thus is an essential part of a document understanding system. In the past, rule-based algorithms have been used to conduct logical layout analysis, using limited size data sets. We here instead focus on supervised learning methods for logical layout analysis. We describe LABA, a system based on multiple support vector machines to perform logical Layout Analysis of scanned Books pages in Arabic. The system detects the function of a text region based on the analysis of various images features and a voting mechanism. For a baseline comparison, we implemented an older but state-of-the-art neural network method. We evaluated LABA using a data set of scanned pages from illustrated Arabic books and obtained high recall and precision values. We also found that the F-measure of LABA is higher for five of the tested six classes compared to the state-of-the-art method. 

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4. Minimally-Supervised Structure-Rich Text Categorization via Learning on Text-Rich Networks

   https://doi.org/10.1145/3442381.3450114  

   Zhang, Xinyang ; Zhang, Chenwei ; Dong, Xin Luna ; Shang, Jingbo ; Han, Jiawei ( April 2021 , WWW '21: The Web Conference 2021)

   null (Ed.)

   Text categorization is an essential task in Web content analysis. Considering the ever-evolving Web data and new emerging categories, instead of the laborious supervised setting, in this paper, we focus on the minimally-supervised setting that aims to categorize documents effectively, with a couple of seed documents annotated per category. We recognize that texts collected from the Web are often structure-rich, i.e., accompanied by various metadata. One can easily organize the corpus into a text-rich network, joining raw text documents with document attributes, high-quality phrases, label surface names as nodes, and their associations as edges. Such a network provides a holistic view of the corpus’ heterogeneous data sources and enables a joint optimization for network-based analysis and deep textual model training. We therefore propose a novel framework for minimally supervised categorization by learning from the text-rich network. Specifically, we jointly train two modules with different inductive biases – a text analysis module for text understanding and a network learning module for class-discriminative, scalable network learning. Each module generates pseudo training labels from the unlabeled document set, and both modules mutually enhance each other by co-training using pooled pseudo labels. We test our model on two real-world datasets. On the challenging e-commerce product categorization dataset with 683 categories, our experiments show that given only three seed documents per category, our framework can achieve an accuracy of about 92%, significantly outperforming all compared methods; our accuracy is only less than 2% away from the supervised BERT model trained on about 50K labeled documents. 

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5. Visual Segmentation for Information Extraction from Heterogeneous Visually Rich Documents

   https://doi.org/10.1145/3299869.3319867  

   Sarkhel, Ritesh ; Nandi, Arnab ( June 2019 , International Conference on Management of Data (SIGMOD), 2019)

   Physical and digital documents often contain visually rich information. With such information, there is no strict order- ing or positioning in the document where the data values must appear. Along with textual cues, these documents often also rely on salient visual features to define distinct semantic boundaries and augment the information they disseminate. When performing information extraction (IE), traditional techniques fall short, as they use a text-only representation and do not consider the visual cues inherent to the layout of these documents. We propose VS2, a generalized approach for information extraction from heterogeneous visually rich documents. There are two major contributions of this work. First, we propose a robust segmentation algorithm that de- composes a visually rich document into a bag of visually iso- lated but semantically coherent areas, called logical blocks. Document type agnostic low-level visual and semantic fea- tures are used in this process. Our second contribution is a distantly supervised search-and-select method for identify- ing the named entities within these documents by utilizing the context boundaries defined by these logical blocks. Ex- perimental results on three heterogeneous datasets suggest that the proposed approach significantly outperforms its text-only counterparts on all datasets. Comparing it against the state-of-the-art methods also reveal that VS2 performs comparably or better on all datasets. 

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