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1. Epigenetic aging of the demographically non-aging naked mole-rat

   https://doi.org/10.1038/s41467-022-27959-9  

   Kerepesi, Csaba ; Meer, Margarita V. ; Ablaeva, Julia ; Amoroso, Vince G. ; Lee, Sang-Goo ; Zhang, Bohan ; Gerashchenko, Maxim V. ; Trapp, Alexandre ; Yim, Sun Hee ; Lu, Ake T. ; et al ( December 2022 , Nature Communications)

   Abstract The naked mole-rat (NMR) is an exceptionally long-lived rodent that shows no increase of mortality with age, defining it as a demographically non-aging mammal. Here, we perform bisulfite sequencing of the blood of > 100 NMRs, assessing > 3 million common CpG sites. Unsupervised clustering based on sites whose methylation correlates with age reveals an age-related methylome remodeling, and we also observe a methylome information loss, suggesting that NMRs age. We develop an epigenetic aging clock that accurately predicts the NMR age. We show that these animals age much slower than mice and much faster than humans, consistent with their known maximum lifespans. Interestingly, patterns of age-related changes of clock sites in Tert and Prpf19 differ between NMRs and mice, but there are also sites conserved between the two species. Together, the data indicate that NMRs, like other mammals, epigenetically age even in the absence of demographic aging of this species. 

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2. Cell-type-specific aging clocks to quantify aging and rejuvenation in neurogenic regions of the brain

   https://doi.org/10.1038/s43587-022-00335-4  

   Buckley, Matthew T. ; Sun, Eric D. ; George, Benson M. ; Liu, Ling ; Schaum, Nicholas ; Xu, Lucy ; Reyes, Jaime M. ; Goodell, Margaret A. ; Weissman, Irving L. ; Wyss-Coray, Tony ; et al ( December 2022 , Nature Aging)

   The diversity of cell types is a challenge for quantifying aging and its reversal. Here we develop ‘aging clocks’ based on single-cell transcriptomics to characterize cell-type-specific aging and rejuvenation. We generated single-cell transcriptomes from the subventricular zone neurogenic region of 28 mice, tiling ages from young to old. We trained single-cell-based regression models to predict chronological age and biological age (neural stem cell proliferation capacity). These aging clocks are generalizable to independent cohorts of mice, other regions of the brains, and other species. To determine if these aging clocks could quantify transcriptomic rejuvenation, we generated single-cell transcriptomic datasets of neurogenic regions for two interventions—heterochronic parabiosis and exercise. Aging clocks revealed that heterochronic parabiosis and exercise reverse transcriptomic aging in neurogenic regions, but in different ways. This study represents the first development of high-resolution aging clocks from single-cell transcriptomic data and demonstrates their application to quantify transcriptomic rejuvenation.

    

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3. A review of aging, degradation, and reusability of PA12 powders in selective laser sintering additive manufacturing

   https://doi.org/10.1016/j.mtcomm.2022.105279  

   Yang, Feifei ; Zobeiry, Navid ; Mamidala, Ramulu ; Chen, Xu ( March 2023 , Materials Today Communications)
4. Physiological and pathological functions of TMEM106B: a gene associated with brain aging and multiple brain disorders

   https://doi.org/10.1007/s00401-020-02246-3  

   Feng, Tuancheng ; Lacrampe, Alexander ; Hu, Fenghua ( January 2021 , Acta Neuropathologica)

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5. Atmospheric aging enhances the ice nucleation ability of biomass-burning aerosol

   https://doi.org/10.1126/sciadv.abd3440  

   Jahl, Lydia G. ; Brubaker, Thomas A. ; Polen, Michael J. ; Jahn, Leif G. ; Cain, Kerrigan P. ; Bowers, Bailey B. ; Fahy, William D. ; Graves, Sara ; Sullivan, Ryan C. ( February 2021 , Science Advances)

   Ice-nucleating particles (INPs) in biomass-burning aerosol (BBA) that affect cloud glaciation, microphysics, precipitation, and radiative forcing were recently found to be driven by the production of mineral phases. BBA experiences extensive chemical aging as the smoke plume dilutes, and we explored how this alters the ice activity of the smoke using simulated atmospheric aging of authentic BBA in a chamber reactor. Unexpectedly, atmospheric aging enhanced the ice activity for most types of fuels and aging schemes. The removal of organic carbon particle coatings that conceal the mineral-based ice-active sites by evaporation or oxidation then dissolution can increase the ice activity by greater than an order of magnitude. This represents a different framework for the evolution of INPs from biomass burning where BBA becomes more ice active as it dilutes and ages, making a larger contribution to the INP budget, resulting cloud microphysics, and climate forcing than is currently considered. 

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