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Title: Annotating the Insect Regulatory Genome
An ever-growing number of insect genomes is being sequenced across the evolutionary spectrum. Comprehensive annotation of not only genes but also regulatory regions is critical for reaping the full benefits of this sequencing. Driven by developments in sequencing technologies and in both empirical and computational discovery strategies, the past few decades have witnessed dramatic progress in our ability to identify cis-regulatory modules (CRMs), sequences such as enhancers that play a major role in regulating transcription. Nevertheless, providing a timely and comprehensive regulatory annotation of newly sequenced insect genomes is an ongoing challenge. We review here the methods being used to identify CRMs in both model and non-model insect species, and focus on two tools that we have developed, REDfly and SCRMshaw. These resources can be paired together in a powerful combination to facilitate insect regulatory annotation over a broad range of species, with an accuracy equal to or better than that of other state-of-the-art methods.  more » « less
Award ID(s):
1758252
PAR ID:
10294608
Author(s) / Creator(s):
;
Date Published:
Journal Name:
Insects
Volume:
12
Issue:
7
ISSN:
2075-4450
Page Range / eLocation ID:
591
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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