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This content will become publicly available on July 19, 2022

Title: Mcl-1 Inhibition: Managing Malignancy in Multiple Myeloma
Multiple myeloma (MM) is a plasma cells neoplasm. The overexpression of Bcl-2 family proteins, particularly myeloid cell leukemia 1 (Mcl-1), plays a critical role in the pathogenesis of MM. The overexpression of Mcl-1 is associated with drug resistance and overall poor prognosis of MM. Thus, inhibition of the Mcl-1 protein considered as a therapeutic strategy to kill the myeloma cells. Over the last decade, the development of selective Mcl-1 inhibitors has seen remarkable advancement. This review presents the critical role of Mcl-1 in the progression of MM, the most prominent BH3 mimetic and semi-BH3 mimetic that selectively inhibit Mcl-1, and could be used as single agent or combined with existing therapies.
Authors:
; ; ; ; ; ; ; ;
Award ID(s):
1827938
Publication Date:
NSF-PAR ID:
10298719
Journal Name:
Frontiers in Pharmacology
Volume:
12
ISSN:
1663-9812
Sponsoring Org:
National Science Foundation
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