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  • 2,3-Diphenyl-2,3-dihydro-4H-1,3-thiaza-4-one heterocycles inhibit growth and block completion of cytokinesis in kinetoplastid parasites
Title: 2,3-Diphenyl-2,3-dihydro-4H-1,3-thiaza-4-one heterocycles inhibit growth and block completion of cytokinesis in kinetoplastid parasites
Award ID(s):
1651517 2041927 2018399
PAR ID:
10298818
Author(s) / Creator(s):
; ; ; ; ; ;
Date Published:
Journal Name:
Molecular and Biochemical Parasitology
Volume:
245
Issue:
C
ISSN:
0166-6851
Page Range / eLocation ID:
111396
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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    Abstract A unified approach to mono- and disubstituted N–H indoles is described by means of oxidative cyclization of 2-alkenyl anilines, which are prepared by cross-coupling of the corresponding o-bromoanilines. This procedure is operationally expedient and tolerant of common functional groups to allow regiospecific installation of the alkyl and aryl substituents. 
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